PABPC5

Protein identityUniProt · HPA

UniProt accession

Q96DU9

Gene

PABPC5

Ensembl

ENSG00000174740

Chromosome

X

Canonical length

382 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a protein that binds to the polyA tail found at the 3' end of most eukaryotic mRNAs. It is thought to play a role in the regulation of mRNA metabolic processes in the cytoplasm. This gene is located in a gene-poor region within the X-specific 13d-sY43 subinterval of the chromosome Xq21.3/Yp11.2 homology block. It is located close to translocation breakpoints associated with premature ovarian failure, and is therefore a potential candidate gene for this disorder. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

382 residues, UniProt reviewed canonical sequence.

>Q96DU9|PABPC5
     1  MGSGEPNPAG KKKKYLKAAL YVGDLDPDVT EDMLYKKFRP AGPLRFTRIC RDPVTRSPLG
    61  YGYVNFRFPA DAEWALNTMN FDLINGKPFR LMWSQPDDRL RKSGVGNIFI KNLDKSIDNR
   121  ALFYLFSAFG NILSCKVVCD DNGSKGYAYV HFDSLAAANR AIWHMNGVRL NNRQVYVGRF
   181  KFPEERAAEV RTRDRATFTN VFVKNIGDDI DDEKLKELFC EYGPTESVKV IRDASGKSKG
   241  FGFVRYETHE AAQKAVLDLH GKSIDGKVLY VGRAQKKIER LAELRRRFER LRLKEKSRPP
   301  GVPIYIKNLD ETINDEKLKE EFSSFGSISR AKVMMEVGQG KGFGVVCFSS FEEATKAVDE
   361  MNGRIVGSKP LHVTLGQARR RC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PABPC5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.33

Highest tissue expression

8.8 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.41

gnomAD pLI

0.89

gnomAD missense Z

1.96

DepMap mean gene effect

-0.02

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

• mRNA 3'-UTR binding
• poly(A) binding
• poly(U) RNA binding

Cellular components

• cytoplasmic stress granule
• cytosol
• mitochondrial matrix
• nucleus
• ribonucleoprotein complex

Protein domainsUniProt · Pfam · InterPro

• RNA recognition motif domain
• RNA recognition motif domain, eukaryotic-type
• Polyadenylate binding protein, human types 1, 2, 3, 4
• Nucleotide-binding alpha-beta plait domain superfamily
• PABP, RNA recognition motif 1
• RNA-binding domain superfamily
• PABP, RNA recognition motif 2
• RNA recognition motif

KeywordsUniProt

• Alternative initiation
• Cytoplasm
• Mitochondrion
• Repeat
• RNA-binding

InteractionsUniProt · HPA

Protein binding partners of PABPC5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PAIP2