Seroatlas · Human Serome Atlas

SYNCRIP

Heterogeneous nuclear ribonucleoprotein Q

Also known as: dJ3J17.2, GRY-RBP, hnRNP-Q, HNRNPQ, HNRPQ_HUMAN, HNRPQ1, NSAP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O60506
Gene
SYNCRIP
Ensembl
ENSG00000135316
Chromosome
6
Canonical length
623 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a member of the cellular heterogeneous nuclear ribonucleoprotein (hnRNP) family. hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA) and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. The encoded protein plays a role in multiple aspects of mRNA maturation and is associated with several multiprotein complexes including the apoB RNA editing-complex and survival of motor neurons (SMN) complex. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 20. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

623 residues, UniProt reviewed canonical sequence.

>O60506|SYNCRIP
     1  MATEHVNGNG TEEPMDTTSA VIHSENFQTL LDAGLPQKVA EKLDEIYVAG LVAHSDLDER
    61  AIEALKEFNE DGALAVLQQF KDSDLSHVQN KSAFLCGVMK TYRQREKQGT KVADSSKGPD
   121  EAKIKALLER TGYTLDVTTG QRKYGGPPPD SVYSGQQPSV GTEIFVGKIP RDLFEDELVP
   181  LFEKAGPIWD LRLMMDPLTG LNRGYAFVTF CTKEAAQEAV KLYNNHEIRS GKHIGVCISV
   241  ANNRLFVGSI PKSKTKEQIL EEFSKVTEGL TDVILYHQPD DKKKNRGFCF LEYEDHKTAA
   301  QARRRLMSGK VKVWGNVGTV EWADPIEDPD PEVMAKVKVL FVRNLANTVT EEILEKAFSQ
   361  FGKLERVKKL KDYAFIHFDE RDGAVKAMEE MNGKDLEGEN IEIVFAKPPD QKRKERKAQR
   421  QAAKNQMYDD YYYYGPPHMP PPTRGRGRGG RGGYGYPPDY YGYEDYYDYY GYDYHNYRGG
   481  YEDPYYGYED FQVGARGRGG RGARGAAPSR GRGAAPPRGR AGYSQRGGPG SARGVRGARG
   541  GAQQQRGRGV RGARGGRGGN VGGKRKADGY NQPDSKRRQT NNQNWGSQPI AQQPLQGGDH
   601  SGNYGYKSEN QEFYQDTFGQ QWK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYNCRIP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
65 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 65 nTPM
  • tonsil: 64 nTPM
  • appendix: 55 nTPM
  • thymus: 55 nTPM
  • lymph node: 54 nTPM
  • thyroid gland: 54 nTPM

Single-cell type

  • microglia: 74 nCPM
  • proximal tubule cells: 54 nCPM
  • distal convoluted tubule cells: 51 nCPM
  • oligodendrocytes: 50 nCPM
  • choroid plexus epithelial cells: 50 nCPM
  • renal connecting tubule cells: 50 nCPM

Immune cell

  • non-classical monocyte: 21 nTPM
  • intermediate monocyte: 19 nTPM
  • NK-cell: 17 nTPM
  • myeloid DC: 14 nTPM
  • gdT-cell: 14 nTPM
  • T-reg: 14 nTPM

Brain region

  • medulla oblongata: 47 nTPM
  • hypothalamus: 46 nTPM
  • cerebellum: 44 nTPM
  • spinal cord: 41 nTPM
  • thalamus: 41 nTPM
  • pons: 41 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SYNCRIP.

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 142 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • SYNCRIP-associated neurodevelopmental disorder
  • SYNCRIP-related neurodevelopmental disorder

Disease | ImmuneIEDB

Conditions an epitope on SYNCRIP was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.21
gnomAD pLI
1
gnomAD missense Z
3.54
DepMap mean gene effect
-0.31
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SYNCRIP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYNCRIP as an antibody target. Whether an autoantibody or antibody against SYNCRIP could matter depends on whether native SYNCRIP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYNCRIP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SYNCRIP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SYNCRIP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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