Seroatlas · Human Serome Atlas

SNRNP35

U11/U12 small nuclear ribonucleoprotein 35 kDa protein

Also known as: U1SBP_HUMAN, U1SNRNPBP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q16560
Gene
SNRNP35
Ensembl
ENSG00000184209
Chromosome
12
Canonical length
246 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli

OverviewNCBI Gene

The protein encoded by this gene is a homolog of the U1-snRNP binding protein. The N-terminal half contains a RNA recognition motif and the C-terminal half is rich in Arg/Asp and Arg/Glu dipeptides, which is a characteristic of a variety of splicing factors. This protein is a component of the U11/U12 small nuclear ribonucleoproteins (snRNP) that form part of the U12-type spliceosome. Alternative splicing results in multiple transcript variants encoding two distinct isoforms and representing a non-protein coding variant. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

246 residues, UniProt reviewed canonical sequence.

>Q16560|SNRNP35
     1  MNDWMPIAKE YDPLKAGSID GTDEDPHDRA VWRAMLARYV PNKGVIGDPL LTLFVARLNL
    61  QTKEDKLKEV FSRYGDIRRL RLVRDLVTGF SKGYAFIEYK EERAVIKAYR DADGLVIDQH
   121  EIFVDYELER TLKGWIPRRL GGGLGGKKES GQLRFGGRDR PFRKPINLPV VKNDLYREGK
   181  RERRERSRSR ERHWDSRTRD RDHDRGREKR WQEREPTRVW PDNDWERERD FRDDRIKGRE
   241  KKERGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNRNP35 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
75 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 75 nTPM
  • choroid plexus: 41 nTPM
  • tongue: 40 nTPM
  • heart muscle: 40 nTPM
  • spinal cord: 32 nTPM
  • spleen: 30 nTPM

Single-cell type

  • cardiomyocytes: 159 nCPM
  • esophageal apical cells: 111 nCPM
  • myonuclei: 90 nCPM
  • neutrophils: 71 nCPM
  • cytotrophoblasts: 63 nCPM
  • esophageal suprabasal cells: 62 nCPM

Immune cell

  • basophil: 81 nTPM
  • T-reg: 80 nTPM
  • eosinophil: 75 nTPM
  • memory B-cell: 72 nTPM
  • neutrophil: 71 nTPM
  • naive B-cell: 67 nTPM

Brain region

  • white matter: 25 nTPM
  • cerebellum: 23 nTPM
  • hypothalamus: 22 nTPM
  • cerebral cortex: 22 nTPM
  • thalamus: 21 nTPM
  • medulla oblongata: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.49
gnomAD pLI
0
gnomAD missense Z
0.8
DepMap mean gene effect
-1.66
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNRNP35 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNRNP35 as an antibody target. Whether an autoantibody or antibody against SNRNP35 could matter depends on whether native SNRNP35 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNRNP35 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNRNP35 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SNRNP35. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...