Seroatlas · Human Serome Atlas

RBM27

RNA-binding protein 27

Also known as: ARRS1, KIAA1311, Psc1, RBM27_HUMAN, ZC3H20

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P2N5
Gene: RBM27
Ensembl: ENSG00000091009
Chromosome: 5
Canonical length: 1060 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be located in cytoplasm and nuclear speck. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1060 residues, UniProt reviewed canonical sequence.

>Q9P2N5|RBM27
     1  MLIEDVDALK SWLAKLLEPI CDADPSALAN YVVALVKKDK PEKELKAFCA DQLDVFLQKE
    61  TSGFVDKLFE SLYTKNYLPL LEPVKPEPKP LVQEKEEIKE EVFQEPAEEE RDGRKKKYPS
   121  PQKTRSESSE RRTREKKRED GKWRDYDRYY ERNELYREKY DWRRGRSKSR SKSRGLSRSR
   181  SRSRGRSKDR DPNRNVEHRE RSKFKSERND LESSYVPVSA PPPNSSEQYS SGAQSIPSTV
   241  TVIAPAHHSE NTTESWSNYY NNHSSSNSFG RNLPPKRRCR DYDERGFCVL GDLCQFDHGN
   301  DPLVVDEVAL PSMIPFPPPP PGLPPPPPPG MLMPPMPGPG PGPGPGPGPG PGPGPGPGHS
   361  MRLPVPQGHG QPPPSVVLPI PRPPITQSSL INSRDQPGTS AVPNLASVGT RLPPPLPQNL
   421  LYTVSERQPM YSREHGAAAS ERLQLGTPPP LLAARLVPPR NLMGSSIGYH TSVSSPTPLV
   481  PDTYEPDGYN PEAPSITSSG RSQYRQFFSR TQTQRPNLIG LTSGDMDVNP RAANIVIQTE
   541  PPVPVSINSN ITRVVLEPDS RKRAMSGLEG PLTKKPWLGK QGNNNQNKPG FLRKNQYTNT
   601  KLEVKKIPQE LNNITKLNEH FSKFGTIVNI QVAFKGDPEA ALIQYLTNEE ARKAISSTEA
   661  VLNNRFIRVL WHRENNEQPT LQSSAQLLLQ QQQTLSHLSQ QHHHLPQHLH QQQVLVAQSA
   721  PSTVHGGIQK MMSKPQTSGA YVLNKVPVKH RLGHAGGNQS DASHLLNQSG GAGEDCQIFS
   781  TPGHPKMIYS SSNLKTPSKL CSGSKSHDVQ EVLKKKQEAM KLQQDMRKKR QEVLEKQIEC
   841  QKMLISKLEK NKNMKPEERA NIMKTLKELG EKISQLKDEL KTSSAVSTPS KVKTKTEAQK
   901  ELLDTELDLH KRLSSGEDTT ELRKKLSQLQ VEAARLGILP VGRGKTMSSQ GRGRGRGRGG
   961  RGRGSLNHMV VDHRPKALTV GGFIEEEKED LLQHFSTANQ GPKFKDRRLQ ISWHKPKVPS
  1021  ISTETEEEEV KEEETETSDL FLPDDDDEDE DEYESRSWRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBM27 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 18 nTPM
thymus: 12 nTPM
lymph node: 11 nTPM
tonsil: 11 nTPM
thyroid gland: 10 nTPM
liver: 9.9 nTPM

Single-cell type

early spermatids: 9.5 nCPM
retinal pigment epithelial cells: 8.5 nCPM
megakaryocyte progenitors: 7.9 nCPM
megakaryocyte-erythroid progenitors: 7.8 nCPM
salivary ionocytes: 6.5 nCPM
erythrocyte progenitors: 6.2 nCPM

Immune cell

naive CD4 T-cell: 1.8 nTPM
NK-cell: 1.8 nTPM
basophil: 1.7 nTPM
eosinophil: 1.6 nTPM
MAIT T-cell: 1.6 nTPM
memory CD8 T-cell: 1.6 nTPM

Brain region

cerebellum: 18 nTPM
hypothalamus: 14 nTPM
thalamus: 14 nTPM
white matter: 14 nTPM
midbrain: 13 nTPM
spinal cord: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.21
gnomAD pLI: 1
gnomAD missense Z: 2.48
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

RNA recognition motif domain
Zinc finger, CCCH-type
PWI domain
Nucleotide-binding alpha-beta plait domain superfamily
RNA-binding domain superfamily
RNA-binding protein 26/27
RNA recognition motif
Zinc finger C-x8-C-x5-C-x3-H type (and similar)
PWI domain
RNA-binding protein 27, RNA recognition motif

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBM27 as an antibody target. Whether an autoantibody or antibody against RBM27 could matter depends on whether native RBM27 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBM27 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBM27 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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