Seroatlas · Human Serome Atlas

RBM34

RNA-binding protein 34

Also known as: KIAA0117, RBM34_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P42696
Gene: RBM34
Ensembl: ENSG00000188739
Chromosome: 1
Canonical length: 430 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Mitotic chromosome

OverviewNCBI Gene

This gene encodes a member of the RNA-binding motif family of RNA recognition motif proteins. The encoded protein contains an RNA-binding domain made up of two RNA recognition motif subdomains referred to as RNA recognition motif-1 and RNA recognition motif-2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]

Canonical amino-acid sequenceUniProt

430 residues, UniProt reviewed canonical sequence.

>P42696|RBM34
     1  MALEGMSKRK RKRSVQEGEN PDDGVRGSPP EDYRLGQVAS SLFRGEHHSR GGTGRLASLF
    61  SSLEPQIQPV YVPVPKQTIK KTKRNEEEES TSQIERPLSQ EPAKKVKAKK KHTNAEKKLA
   121  DRESALASAD LEEEIHQKQG QKRKNSQPGV KVADRKILDD TEDTVVSQRK KIQINQEEER
   181  LKNERTVFVG NLPVTCNKKK LKSFFKEYGQ IESVRFRSLI PAEGTLSKKL AAIKRKIHPD
   241  QKNINAYVVF KEESAATQAL KRNGAQIADG FRIRVDLASE TSSRDKRSVF VGNLPYKVEE
   301  SAIEKHFLDC GSIMAVRIVR DKMTGIGKGF GYVLFENTDS VHLALKLNNS ELMGRKLRVM
   361  RSVNKEKFKQ QNSNPRLKNV SKPKQGLNFT SKTAEGHPKS LFIGEKAVLL KTKKKGQKKS
   421  GRPKKQRKQK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBM34 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 34 nTPM
skeletal muscle: 23 nTPM
lymph node: 22 nTPM
testis: 20 nTPM
tonsil: 19 nTPM
salivary gland: 19 nTPM

Single-cell type

choroid plexus epithelial cells: 38 nCPM
microglia: 37 nCPM
oligodendrocytes: 21 nCPM
oligodendrocyte progenitor cells: 19 nCPM
other brain neurons: 19 nCPM
brain inhibitory neurons: 18 nCPM

Immune cell

basophil: 114 nTPM
T-reg: 78 nTPM
memory B-cell: 74 nTPM
memory CD8 T-cell: 60 nTPM
plasmacytoid DC: 60 nTPM
NK-cell: 58 nTPM

Brain region

medulla oblongata: 16 nTPM
spinal cord: 15 nTPM
white matter: 15 nTPM
pons: 15 nTPM
midbrain: 14 nTPM
hypothalamus: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.43
gnomAD pLI: 0
gnomAD missense Z: -0.39
DepMap mean gene effect: -0.22
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

LSU-rRNA)
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA
5.8S rRNA

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

RNA recognition motif domain
Nucleotide-binding alpha-beta plait domain superfamily
RNA-binding domain superfamily
RNA recognition motif
RBM34, RNA recognition motif 2

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RBM34 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBM34 as an antibody target. Whether an autoantibody or antibody against RBM34 could matter depends on whether native RBM34 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBM34 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBM34 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...