Seroatlas · Human Serome Atlas

SNRPB2

U2 small nuclear ribonucleoprotein B''

Also known as: Msl1, RU2B_HUMAN, U2B''

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P08579
Gene: SNRPB2
Ensembl: ENSG00000125870
Chromosome: 20
Canonical length: 225 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nuclear speckles,Cytoplasmic bodies

OverviewNCBI Gene

The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

225 residues, UniProt reviewed canonical sequence.

>P08579|SNRPB2
     1  MDIRPNHTIY INNMNDKIKK EELKRSLYAL FSQFGHVVDI VALKTMKMRG QAFVIFKELG
    61  SSTNALRQLQ GFPFYGKPMR IQYAKTDSDI ISKMRGTFAD KEKKKEKKKA KTVEQTATTT
   121  NKKPGQGTPN SANTQGNSTP NPQVPDYPPN YILFLNNLPE ETNEMMLSML FNQFPGFKEV
   181  RLVPGRHDIA FVEFENDGQA GAARDALQGF KITPSHAMKI TYAKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNRPB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 51 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 51 nTPM
lymph node: 40 nTPM
kidney: 39 nTPM
thymus: 35 nTPM
tonsil: 34 nTPM
epididymis: 33 nTPM

Single-cell type

oocytes: 548 nCPM
syncytiotrophoblasts: 488 nCPM
late primary spermatocytes: 386 nCPM
migrating cytotrophoblasts: 381 nCPM
extravillous trophoblasts: 357 nCPM
parietal cells: 332 nCPM

Immune cell

basophil: 52 nTPM
T-reg: 48 nTPM
eosinophil: 48 nTPM
plasmacytoid DC: 46 nTPM
non-classical monocyte: 41 nTPM
intermediate monocyte: 39 nTPM

Brain region

white matter: 25 nTPM
choroid plexus: 23 nTPM
hypothalamus: 23 nTPM
spinal cord: 22 nTPM
cerebral cortex: 22 nTPM
midbrain: 21 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SNRPB2.

Disease | ImmuneIEDB

Conditions an epitope on SNRPB2 was assayed in.

systemic lupus erythematosus B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.8
gnomAD pLI: 0.05
gnomAD missense Z: 1.77
DepMap mean gene effect: -0.74
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

U1 snRNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

RNA recognition motif domain
Nucleotide-binding alpha-beta plait domain superfamily
RNA-binding domain superfamily
RNA recognition motif
U2 small nuclear ribonucleoprotein B'', RNA recognition motif 2
U2 small nuclear ribonucleoprotein B'', RNA recognition motif 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNRPB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNRPB2 as an antibody target. Whether an autoantibody or antibody against SNRPB2 could matter depends on whether native SNRPB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNRPB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein.

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