Seroatlas · Human Serome Atlas

ELAVL3

ELAV-like protein 3

Also known as: DKFZp547J036, ELAV3_HUMAN, HUC, HUCL, MGC20653, PLE21

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14576
Gene: ELAVL3
Ensembl: ENSG00000196361
Chromosome: 19
Canonical length: 367 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

367 residues, UniProt reviewed canonical sequence.

>Q14576|ELAVL3
     1  MVTQILGAME SQVGGGPAGP ALPNGPLLGT NGATDDSKTN LIVNYLPQNM TQDEFKSLFG
    61  SIGDIESCKL VRDKITGQSL GYGFVNYSDP NDADKAINTL NGLKLQTKTI KVSYARPSSA
   121  SIRDANLYVS GLPKTMSQKE MEQLFSQYGR IITSRILVDQ VTGVSRGVGF IRFDKRIEAE
   181  EAIKGLNGQK PLGAAEPITV KFANNPSQKT GQALLTHLYQ SSARRYAGPL HHQTQRFRLD
   241  NLLNMAYGVK SPLSLIARFS PIAIDGMSGL AGVGLSGGAA GAGWCIFVYN LSPEADESVL
   301  WQLFGPFGAV TNVKVIRDFT TNKCKGFGFV TMTNYDEAAM AIASLNGYRL GERVLQVSFK
   361  TSKQHKA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ELAVL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 145 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 145 nTPM
spinal cord: 76 nTPM
hippocampal formation: 58 nTPM
cerebral cortex: 56 nTPM
midbrain: 46 nTPM
amygdala: 46 nTPM

Single-cell type

oligodendrocytes: 158 nCPM
retinal amacrine cells: 142 nCPM
brain excitatory neurons: 133 nCPM
retinal ganglion cells: 112 nCPM
brain inhibitory neurons: 105 nCPM
other brain neurons: 98 nCPM

Immune cell

memory B-cell: 0.4 nTPM
naive B-cell: 0.4 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

white matter: 245 nTPM
cerebellum: 217 nTPM
cerebral cortex: 173 nTPM
pons: 167 nTPM
medulla oblongata: 157 nTPM
basal ganglia: 151 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.46
gnomAD pLI: 0.77
gnomAD missense Z: 3
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

mRNA 3'-UTR AU-rich region binding

Cellular components

ribonucleoprotein complex

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ELAVL3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ELAVL3 as an antibody target. Whether an autoantibody or antibody against ELAVL3 could matter depends on whether native ELAVL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ELAVL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis.

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