PPARGC1A

Protein identityUniProt · HPA

UniProt accession

Q9UBK2

Gene

PPARGC1A

Ensembl

ENSG00000109819

Chromosome

4

Canonical length

798 aa

Protein class

Cancer-related genes, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

Quaternary structure

Homooligomer

OverviewNCBI Gene

The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

798 residues, UniProt reviewed canonical sequence.

>Q9UBK2|PPARGC1A
     1  MAWDMCNQDS ESVWSDIECA ALVGEDQPLC PDLPELDLSE LDVNDLDTDS FLGGLKWCSD
    61  QSEIISNQYN NEPSNIFEKI DEENEANLLA VLTETLDSLP VDEDGLPSFD ALTDGDVTTD
   121  NEASPSSMPD GTPPPQEAEE PSLLKKLLLA PANTQLSYNE CSGLSTQNHA NHNHRIRTNP
   181  AIVKTENSWS NKAKSICQQQ KPQRRPCSEL LKYLTTNDDP PHTKPTENRN SSRDKCTSKK
   241  KSHTQSQSQH LQAKPTTLSL PLTPESPNDP KGSPFENKTI ERTLSVELSG TAGLTPPTTP
   301  PHKANQDNPF RASPKLKSSC KTVVPPPSKK PRYSESSGTQ GNNSTKKGPE QSELYAQLSK
   361  SSVLTGGHEE RKTKRPSLRL FGDHDYCQSI NSKTEILINI SQELQDSRQL ENKDVSSDWQ
   421  GQICSSTDSD QCYLRETLEA SKQVSPCSTR KQLQDQEIRA ELNKHFGHPS QAVFDDEADK
   481  TGELRDSDFS NEQFSKLPMF INSGLAMDGL FDDSEDESDK LSYPWDGTQS YSLFNVSPSC
   541  SSFNSPCRDS VSPPKSLFSQ RPQRMRSRSR SFSRHRSCSR SPYSRSRSRS PGSRSSSRSC
   601  YYYESSHYRH RTHRNSPLYV RSRSRSPYSR RPRYDSYEEY QHERLKREEY RREYEKRESE
   661  RAKQRERQRQ KAIEERRVIY VGKIRPDTTR TELRDRFEVF GEIEECTVNL RDDGDSYGFI
   721  TYRYTCDAFA ALENGYTLRR SNETDFELYF CGRKQFFKSN YADLDSNSDD FDPASTKSKY
   781  DSLDFDSLLK EAQRSLRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPARGC1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.63

Highest tissue expression

42 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.27

gnomAD pLI

1

gnomAD missense Z

1

DepMap mean gene effect

0.08

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adipose tissue development
• brown fat cell differentiation
• cellular respiration
• cellular response to oxidative stress
• circadian regulation of gene expression
• digestion
• energy homeostasis
• fatty acid oxidation
• gluconeogenesis
• intracellular glucose homeostasis
• mitochondrion organization
• mRNA processing
• negative regulation of neuron apoptotic process
• negative regulation of smooth muscle cell proliferation
• neuron apoptotic process
• positive regulation of cold-induced thermogenesis
• positive regulation of DNA-templated transcription
• positive regulation of fatty acid oxidation
• positive regulation of gene expression
• positive regulation of gluconeogenesis
• positive regulation of transcription by RNA polymerase II
• protein stabilization
• protein-containing complex assembly
• regulation of circadian rhythm
• regulation of DNA-templated transcription
• respiratory electron transport chain
• response to dietary excess
• response to muscle activity
• response to starvation
• RNA splicing
• temperature homeostasis
• transcription initiation at RNA polymerase II promoter

Molecular functions

• chromatin DNA binding
• DNA binding
• DNA-binding transcription factor binding
• lncRNA binding
• nuclear receptor binding
• RNA binding
• RNA polymerase II-specific DNA-binding transcription factor binding
• sequence-specific DNA binding
• transcription coactivator activity
• transcription coregulator activity
• ubiquitin protein ligase binding

Cellular components

• chromatin
• cytosol
• nucleoplasm
• nucleus
• PML body

Protein domainsUniProt · Pfam · InterPro

• RNA recognition motif domain
• Nucleotide-binding alpha-beta plait domain superfamily
• PGC-1
• RNA-binding domain superfamily
• RNA recognition motif
• PGC-1alpha, RNA recognition motif

KeywordsUniProt

• Acetylation
• Activator
• Alternative promoter usage
• Biological rhythms
• Cytoplasm
• Nucleus
• Phosphoprotein
• RNA-binding
• Transcription
• Transcription regulation
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of PPARGC1A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• FOXO1
• LPIN1
• LRPPRC
• MYBBP1A
• NR5A2
• PML
• PRDM16
• NR5A1
• NR1H4
• NR2F2
• MED1
• RORA
• ESRRA
• ESRRG
• HNF4A
• PPARG