Seroatlas · Human Serome Atlas

RBM4B

RNA-binding protein 4B

Also known as: MGC10871, RBM30, RBM4B_HUMAN, RBM4L, ZCCHC15, ZCCHC21B, ZCRB3B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BQ04
Gene: RBM4B
Ensembl: ENSG00000173914
Chromosome: 11
Canonical length: 359 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in circadian regulation of gene expression; entrainment of circadian clock by photoperiod; and regulation of translation. Predicted to act upstream of or within positive regulation of gene expression. Located in cytosol and nucleoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

359 residues, UniProt reviewed canonical sequence.

>Q9BQ04|RBM4B
     1  MVKLFIGNLP REATEQEIRS LFEQYGKVLE CDIIKNYGFV HIEDKTAAED AIRNLHHYKL
    61  HGVNINVEAS KNKSKASTKL HVGNISPTCT NQELRAKFEE YGPVIECDIV KDYAFVHMER
   121  AEDAVEAIRG LDNTEFQGKR MHVQLSTSRL RTAPGMGDQS GCYRCGKEGH WSKECPVDRT
   181  GRVADFTEQY NEQYGAVRTP YTMGYGESMY YNDAYGALDY YKRYRVRSYE AVAAAAAASA
   241  YNYAEQTMSH LPQVQSTTVT SHLNSTSVDP YDRHLLPNSG AAATSAAMAA AAATTSSYYG
   301  RDRSPLRRAA AMLPTVGEGY GYGPESELSQ ASAATRNSLY DMARYEREQY VDRARYSAF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBM4B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 42 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 42 nTPM
retina: 32 nTPM
ovary: 26 nTPM
pituitary gland: 23 nTPM
cervix: 23 nTPM
spinal cord: 22 nTPM

Single-cell type

cardiomyocytes: 166 nCPM
myonuclei: 120 nCPM
rod photoreceptor cells: 92 nCPM
early primary spermatocytes: 79 nCPM
epicardial cells: 75 nCPM
late spermatids: 72 nCPM

Immune cell

eosinophil: 44 nTPM
memory B-cell: 35 nTPM
naive B-cell: 29 nTPM
basophil: 26 nTPM
non-classical monocyte: 26 nTPM
intermediate monocyte: 23 nTPM

Brain region

cerebellum: 53 nTPM
cerebral cortex: 39 nTPM
white matter: 38 nTPM
hypothalamus: 35 nTPM
basal ganglia: 31 nTPM
amygdala: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0.02
gnomAD missense Z: 0.67
DepMap mean gene effect: -0.28
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RBM4B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBM4B as an antibody target. Whether an autoantibody or antibody against RBM4B could matter depends on whether native RBM4B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBM4B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBM4B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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