Seroatlas · Human Serome Atlas

RBPMS2

RNA-binding protein with multiple splicing 2

Also known as: RBPS2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZRY4
Gene: RBPMS2
Ensembl: ENSG00000166831
Chromosome: 15
Canonical length: 209 aa
Protein class: Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the RNA recognition motif (RRM)-containing protein family and is involved in the development and dedifferentiation of digestive smooth muscle cells. The encoded protein functions as a homodimer and indirectly inhibits the bone morphogenetic protein pathway. [provided by RefSeq, Aug 2016]

Canonical amino-acid sequenceUniProt

209 residues, UniProt reviewed canonical sequence.

>Q6ZRY4|RBPMS2
     1  MSNLKPDGEH GGSTGTGSGA GSGGALEEEV RTLFVSGLPV DIKPRELYLL FRPFKGYEGS
    61  LIKLTARQPV GFVIFDSRAG AEAAKNALNG IRFDPENPQT LRLEFAKANT KMAKSKLMAT
   121  PNPSNVHPAL GAHFIARDPY DLMGAALIPA SPEAWAPYPL YTTELTPAIS HAAFTYPTAT
   181  AAAAALHAQV RWYPSSDTTQ QGWKYRQFC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBPMS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 284 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 284 nTPM
blood vessel: 138 nTPM
colon: 138 nTPM
urinary bladder: 92 nTPM
endometrium: 49 nTPM
stomach: 48 nTPM

Single-cell type

megakaryocytes: 420 nCPM
vascular smooth muscle cells: 136 nCPM
smooth muscle cells: 126 nCPM
platelets: 126 nCPM
megakaryocyte progenitors: 95 nCPM
parietal cells: 69 nCPM

Immune cell

naive B-cell: 0.7 nTPM
memory B-cell: 0.4 nTPM
total PBMC: 0.4 nTPM
NK-cell: 0.2 nTPM
memory CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM

Brain region

choroid plexus: 29 nTPM
thalamus: 24 nTPM
cerebral cortex: 11 nTPM
amygdala: 8.7 nTPM
midbrain: 8.3 nTPM
hypothalamus: 6.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.42
gnomAD pLI: 0.88
gnomAD missense Z: 0.94
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

RNA recognition motif domain
Nucleotide-binding alpha-beta plait domain superfamily
RNA-binding domain superfamily
RNA recognition motif
RBPMS2, RNA recognition motif

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RBPMS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBPMS2 as an antibody target. Whether an autoantibody or antibody against RBPMS2 could matter depends on whether native RBPMS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBPMS2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBPMS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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