Seroatlas · Human Serome Atlas

RBM7

RNA-binding protein 7

Also known as: RBM7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y580
Gene: RBM7
Ensembl: ENSG00000076053
Chromosome: 11
Canonical length: 266 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables 14-3-3 protein binding activity; pre-mRNA intronic binding activity; and snRNA binding activity. Involved in snRNA catabolic process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

266 residues, UniProt reviewed canonical sequence.

>Q9Y580|RBM7
     1  MGAAAAEADR TLFVGNLETK VTEELLFELF HQAGPVIKVK IPKDKDGKPK QFAFVNFKHE
    61  VSVPYAMNLL NGIKLYGRPI KIQFRSGSSH APQDVSLSYP QHHVGNSSPT STSPSRYERT
   121  MDNMTSSAQI IQRSFSSPEN FQRQAVMNSA LRQMSYGGKF GSSPLDQSGF SPSVQSHSHS
   181  FNQSSSSQWR QGTPSSQRKV RMNSYPYLAD RHYSREQRYT DHGSDHHYRG KRDDFFYEDR
   241  NHDDWSHDYD NRRDSSRDGK WRSSRH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBM7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 38 nTPM
liver: 17 nTPM
thymus: 14 nTPM
tongue: 14 nTPM
ovary: 13 nTPM
breast: 12 nTPM

Single-cell type

cardiomyocytes: 64 nCPM
adipocytes: 20 nCPM
early spermatids: 14 nCPM
epicardial cells: 14 nCPM
late primary spermatocytes: 9.5 nCPM
endometrial secretory cells: 7.1 nCPM

Immune cell

basophil: 53 nTPM
eosinophil: 18 nTPM
NK-cell: 17 nTPM
non-classical monocyte: 17 nTPM
classical monocyte: 15 nTPM
MAIT T-cell: 15 nTPM

Brain region

cerebellum: 18 nTPM
medulla oblongata: 16 nTPM
white matter: 16 nTPM
basal ganglia: 14 nTPM
hypothalamus: 14 nTPM
spinal cord: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.52
gnomAD pLI: 0.65
gnomAD missense Z: 0.83
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

RNA recognition motif domain
Nucleotide-binding alpha-beta plait domain superfamily
RNA-binding domain superfamily
Nuclear exosome targeting complex subunit
RNA recognition motif
RBM7, RNA recognition motif

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RBM7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBM7 as an antibody target. Whether an autoantibody or antibody against RBM7 could matter depends on whether native RBM7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBM7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBM7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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