Seroatlas · Human Serome Atlas

RBMY1E

RNA-binding motif protein, Y chromosome, family 1 member E

Also known as: RBY1E_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NEQ0
Gene: RBMY1E
Ensembl: ENSG00000242389
Chromosome: Y
Canonical length: 496 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. Multiple copies of this gene are found in the AZFb azoospermia factor region of chromosome Y and the encoded protein is thought to be involved in spermatogenesis. Most copies of this locus are pseudogenes, although six highly similar copies have full-length ORFs and are considered functional. Four functional copies of this gene are found within inverted repeat IR2; two functional copies of this gene are found in palindrome P3, along with two copies of PTPN13-like, Y-linked. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

496 residues, UniProt reviewed canonical sequence.

>A6NEQ0|RBMY1E
     1  MVEADHPGKL FIGGLNRETN EKMLKAVFGK HGPISEVLLI KDRTSKSRGF AFITFENPAD
    61  AKNAAKDMNG KSLHGKAIKV EQAKKPSFQS GGRRRPPASS RNRSPSGSLR SARGSRGGTR
   121  GWLPSQEGHL DDGGYTPDLK MSYSRGLIPV KRGPSSRSGG PPPKKSAPSA VARSNSWMGS
   181  QGPMSQRREN YGVPPRRATI SSWRNDRMST RHDGYATNDG NHPSCQETRD YAPPSRGYAY
   241  RDNGHSNRDE HSSRGYRNHR SSRETRDYAP PSRGHAYRDY GHSRRDESYS RGYRNRRSSR
   301  ETREYAPPSR GHGYRDYGHS RRHESYSRGY RNHPSSRETR DYAPPHRDYA YRDYGHSSWD
   361  EHSSRGYSYH DGYGEALGRD HSEHLSGSSY RDALQRYGTA HGAPPARGPR MSYGGSTCHA
   421  YSNTRDRYGR SWESYSSCGD FHYCDREHVC RKDQRNPPSL GRVLPDPREA CGSSSYVASI
   481  VDGGESRSEK GDSSRY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBMY1E can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 2.6 nTPM

Expression across tissuesHPA

Tissue

testis: 2.6 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

early primary spermatocytes: 2 nCPM
differentiating spermatogonia: 1.4 nCPM
late primary spermatocytes: 0.6 nCPM
undifferentiated spermatogonia: 0.2 nCPM
early spermatids: 0.1 nCPM
late spermatids: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.89
gnomAD pLI: 0.29
gnomAD missense Z: -0.49

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RBMY1E in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

KHDRBS3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBMY1E as an antibody target. Whether an autoantibody or antibody against RBMY1E could matter depends on whether native RBMY1E is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBMY1E is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBMY1E as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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