Seroatlas · Human Serome Atlas

SRSF5

Serine/arginine-rich splicing factor 5

Also known as: HRS, SFRS5, SRP40, SRSF5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13243
Gene
SRSF5
Ensembl
ENSG00000100650
Chromosome
14
Canonical length
272 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

272 residues, UniProt reviewed canonical sequence.

>Q13243|SRSF5
     1  MSGCRVFIGR LNPAAREKDV ERFFKGYGRI RDIDLKRGFG FVEFEDPRDA DDAVYELDGK
    61  ELCSERVTIE HARARSRGGR GRGRYSDRFS SRRPRNDRRN APPVRTENRL IVENLSSRVS
   121  WQDLKDFMRQ AGEVTFADAH RPKLNEGVVE FASYGDLKNA IEKLSGKEIN GRKIKLIEGS
   181  KRHSRSRSRS RSRTRSSSRS RSRSRSRSRK SYSRSRSRSR SRSRSKSRSV SRSPVPEKSQ
   241  KRGSSSRSKS PASVDRQRSR SRSRSRSVDS GN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRSF5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
431 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 431 nTPM
  • skin: 260 nTPM
  • fallopian tube: 241 nTPM
  • small intestine: 239 nTPM
  • choroid plexus: 235 nTPM
  • blood vessel: 230 nTPM

Single-cell type

  • esophageal apical cells: 3,025 nCPM
  • syncytiotrophoblasts: 965 nCPM
  • migrating cytotrophoblasts: 630 nCPM
  • epididymal basal cells: 623 nCPM
  • epididymal principal cells: 601 nCPM
  • esophageal suprabasal cells: 557 nCPM

Immune cell

  • neutrophil: 163 nTPM
  • basophil: 138 nTPM
  • non-classical monocyte: 130 nTPM
  • intermediate monocyte: 118 nTPM
  • memory B-cell: 110 nTPM
  • naive B-cell: 109 nTPM

Brain region

  • choroid plexus: 245 nTPM
  • white matter: 179 nTPM
  • cerebral cortex: 161 nTPM
  • medulla oblongata: 140 nTPM
  • hippocampal formation: 139 nTPM
  • pons: 136 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.46
gnomAD pLI
0.69
gnomAD missense Z
1.31
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SRSF5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRSF5 as an antibody target. Whether an autoantibody or antibody against SRSF5 could matter depends on whether native SRSF5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRSF5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SRSF5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SRSF5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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