Seroatlas · Human Serome Atlas

TRNAU1AP

tRNA selenocysteine 1-associated protein 1

Also known as: FLJ20503, SECP43, TRSPAP1, TSAP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NX07
Gene: TRNAU1AP
Ensembl: ENSG00000180098
Chromosome: 1
Canonical length: 287 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in selenocysteine incorporation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

287 residues, UniProt reviewed canonical sequence.

>Q9NX07|TRNAU1AP
     1  MAASLWMGDL EPYMDENFIS RAFATMGETV MSVKIIRNRL TGIPAGYCFV EFADLATAEK
    61  CLHKINGKPL PGATPAKRFK LNYATYGKQP DNSPEYSLFV GDLTPDVDDG MLYEFFVKVY
   121  PSCRGGKVVL DQTGVSKGYG FVKFTDELEQ KRALTECQGA VGLGSKPVRL SVAIPKASRV
   181  KPVEYSQMYS YSYNQYYQQY QNYYAQWGYD QNTGSYSYSY PQYGYTQSTM QTYEEVGDDA
   241  LEDPMPQLDV TEANKEFMEQ SEELYDALMD CHWQPLDTVS SEIPAMM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRNAU1AP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 8.7 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 8.7 nTPM
thymus: 7.9 nTPM
choroid plexus: 7.1 nTPM
retina: 6.7 nTPM
skin: 6.5 nTPM
tonsil: 6.5 nTPM

Single-cell type

esophageal apical cells: 124 nCPM
syncytiotrophoblasts: 120 nCPM
respiratory ciliated cells: 95 nCPM
urothelial cells: 86 nCPM
myonuclei: 78 nCPM
extravillous trophoblasts: 78 nCPM

Immune cell

NK-cell: 9.8 nTPM
eosinophil: 7.3 nTPM
basophil: 5.4 nTPM
naive CD4 T-cell: 5.4 nTPM
memory CD8 T-cell: 5.3 nTPM
intermediate monocyte: 4.5 nTPM

Brain region

cerebellum: 9.7 nTPM
white matter: 7.6 nTPM
medulla oblongata: 6.5 nTPM
hypothalamus: 6.4 nTPM
basal ganglia: 6.3 nTPM
pons: 6.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.83
gnomAD pLI: 0
gnomAD missense Z: 1.67
DepMap mean gene effect: -0.28
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

selenocysteine incorporation

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRNAU1AP as an antibody target. Whether an autoantibody or antibody against TRNAU1AP could matter depends on whether native TRNAU1AP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRNAU1AP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRNAU1AP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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