Seroatlas · Human Serome Atlas

RBM5

RNA-binding protein 5

Also known as: H37, LUCA-15, LUCA15, RBM5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P52756
Gene
RBM5
Ensembl
ENSG00000003756
Chromosome
3
Canonical length
815 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Perinuclear theca,Flagellar centriole,Mid piece,Principal piece,End piece

OverviewNCBI Gene

This gene is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of the spliceosome A complex. The encoded protein plays a role in the induction of cell cycle arrest and apoptosis through pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. This gene is located within the tumor suppressor region 3p21.3, and may play a role in the inhibition of tumor transformation and progression of several malignancies including lung cancer. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

815 residues, UniProt reviewed canonical sequence.

>P52756|RBM5
     1  MGSDKRVSRT ERSGRYGSII DRDDRDERES RSRRRDSDYK RSSDDRRGDR YDDYRDYDSP
    61  ERERERRNSD RSEDGYHSDG DYGEHDYRHD ISDERESKTI MLRGLPITIT ESDIREMMES
   121  FEGPQPADVR LMKRKTGVSR GFAFVEFYHL QDATSWMEAN QKKLVIQGKH IAMHYSNPRP
   181  KFEDWLCNKC CLNNFRKRLK CFRCGADKFD SEQEVPPGTT ESVQSVDYYC DTIILRNIAP
   241  HTVVDSIMTA LSPYASLAVN NIRLIKDKQT QQNRGFAFVQ LSSAMDASQL LQILQSLHPP
   301  LKIDGKTIGV DFAKSARKDL VLSDGNRVSA FSVASTAIAA AQWSSTQSQS GEGGSVDYSY
   361  LQPGQDGYAQ YAQYSQDYQQ FYQQQAGGLE SDASSASGTA VTTTSAAVVS QSPQLYNQTS
   421  NPPGSPTEEA QPSTSTSTQA PAASPTGVVP GTKYAVPDTS TYQYDESSGY YYDPTTGLYY
   481  DPNSQYYYNS LTQQYLYWDG EKETYVPAAE SSSHQQSGLP PAKEGKEKKE KPKSKTAQQI
   541  AKDMERWAKS LNKQKENFKN SFQPVNSLRE EERRESAAAD AGFALFEKKG ALAERQQLIP
   601  ELVRNGDEEN PLKRGLVAAY SGDSDNEEEL VERLESEEEK LADWKKMACL LCRRQFPNKD
   661  ALVRHQQLSD LHKQNMDIYR RSRLSEQELE ALELREREMK YRDRAAERRE KYGIPEPPEP
   721  KRKKQFDAGT VNYEQPTKDG IDHSNIGNKM LQAMGWREGS GLGRKCQGIT APIEAQVRLK
   781  GAGLGAKGSA YGLSGADSYK DAVRKAMFAR FTEME

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBM5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
116 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 116 nTPM
  • cervix: 96 nTPM
  • spleen: 92 nTPM
  • fallopian tube: 89 nTPM
  • retina: 84 nTPM
  • prostate: 83 nTPM

Single-cell type

  • late spermatids: 325 nCPM
  • neutrophils: 215 nCPM
  • choroid plexus epithelial cells: 179 nCPM
  • pituicytes/fscs: 179 nCPM
  • neutrophil progenitors: 176 nCPM
  • early spermatids: 172 nCPM

Immune cell

  • basophil: 55 nTPM
  • neutrophil: 39 nTPM
  • eosinophil: 29 nTPM
  • T-reg: 29 nTPM
  • naive CD4 T-cell: 28 nTPM
  • memory CD8 T-cell: 26 nTPM

Brain region

  • white matter: 98 nTPM
  • hypothalamus: 81 nTPM
  • choroid plexus: 72 nTPM
  • cerebellum: 72 nTPM
  • medulla oblongata: 69 nTPM
  • pons: 67 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RBM5.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 101 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Male infertility with azoospermia or oligozoospermia due to single gene mutation

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.14
gnomAD pLI
1
gnomAD missense Z
4.17
DepMap mean gene effect
-0.21
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RBM5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBM5 as an antibody target. Whether an autoantibody or antibody against RBM5 could matter depends on whether native RBM5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBM5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBM5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RBM5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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