RBM17
Splicing factor 45
Also known as: MGC14439, SPF45, SPF45_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96I25
- Gene
- RBM17
- Ensembl
- ENSG00000134453
- Chromosome
- 10
- Canonical length
- 401 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
This gene encodes an RNA binding protein. The encoded protein is part of the spliceosome complex and functions in the second catalytic step of mRNA splicing. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 9 and 15. [provided by RefSeq, Mar 2009]
Canonical amino-acid sequenceUniProt
401 residues, UniProt reviewed canonical sequence.
>Q96I25|RBM17
1 MSLYDDLGVE TSDSKTEGWS KNFKLLQSQL QVKKAALTQA KSQRTKQSTV LAPVIDLKRG
61 GSSDDRQIVD TPPHVAAGLK DPVPSGFSAG EVLIPLADEY DPMFPNDYEK VVKRQREERQ
121 RQRELERQKE IEEREKRRKD RHEASGFARR PDPDSDEDED YERERRKRSM GGAAIAPPTS
181 LVEKDKELPR DFPYEEDSRP RSQSSKAAIP PPVYEEQDRP RSPTGPSNSF LANMGGTVAH
241 KIMQKYGFRE GQGLGKHEQG LSTALSVEKT SKRGGKIIVG DATEKDASKK SDSNPLTEIL
301 KCPTKVVLLR NMVGAGEVDE DLEVETKEEC EKYGKVGKCV IFEIPGAPDD EAVRIFLEFE
361 RVESAIKAVV DLNGRYFGGR VVKACFYNLD KFRVLDLAEQ VLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RBM17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.54
- Highest tissue expression
- 132 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 132 nTPM
- skeletal muscle: 94 nTPM
- lymph node: 82 nTPM
- thymus: 82 nTPM
- tonsil: 80 nTPM
- lung: 78 nTPM
Single-cell type
- early primary spermatocytes: 331 nCPM
- extravillous trophoblasts: 229 nCPM
- differentiating spermatogonia: 203 nCPM
- migrating cytotrophoblasts: 202 nCPM
- erythrocyte progenitors: 190 nCPM
- oocytes: 189 nCPM
Immune cell
- naive B-cell: 111 nTPM
- eosinophil: 103 nTPM
- memory B-cell: 102 nTPM
- T-reg: 101 nTPM
- basophil: 80 nTPM
- intermediate monocyte: 79 nTPM
Brain region
- medulla oblongata: 80 nTPM
- thalamus: 79 nTPM
- cerebral cortex: 78 nTPM
- hypothalamus: 77 nTPM
- pons: 76 nTPM
- white matter: 75 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.12
- gnomAD pLI
- 1
- gnomAD missense Z
- 3.1
- DepMap mean gene effect
- -1.31
- DepMap dependency class
- common
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of RBM17 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RBM17 as an antibody target. Whether an autoantibody or antibody against RBM17 could matter depends on whether native RBM17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RBM17 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label RBM17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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