UHMK1

Protein identityUniProt · HPA

UniProt accession

Q8TAS1

Gene

UHMK1

Ensembl

ENSG00000152332

Chromosome

1

Canonical length

419 aa

Protein class

Enzymes, Predicted intracellular proteins

Subcellular location

Nucleoplasm

OverviewNCBI Gene

The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

419 residues, UniProt reviewed canonical sequence.

>Q8TAS1|UHMK1
     1  MAGSGCAWGA EPPRFLEAFG RLWQVQSRLG SGSSASVYRV RCCGNPGSPP GALKQFLPPG
    61  TTGAAASAAE YGFRKERAAL EQLQGHRNIV TLYGVFTIHF SPNVPSRCLL LELLDVSVSE
   121  LLLYSSHQGC SMWMIQHCAR DVLEALAFLH HEGYVHADLK PRNILWSAEN ECFKLIDFGL
   181  SFKEGNQDVK YIQTDGYRAP EAELQNCLAQ AGLQSDTECT SAVDLWSLGI ILLEMFSGMK
   241  LKHTVRSQEW KANSSAIIDH IFASKAVVNA AIPAYHLRDL IKSMLHDDPS RRIPAEMALC
   301  SPFFSIPFAP HIEDLVMLPT PVLRLLNVLD DDYLENEEEY EDVVEDVKEE CQKYGPVVSL
   361  LVPKENPGRG QVFVEYANAG DSKAAQKLLT GRMFDGKFVV ATFYPLSAYK RGYLYQTLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UHMK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.26

Highest tissue expression

38 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about UHMK1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 66 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Cerebral visual impairment and intellectual disability

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.41

gnomAD pLI

0.83

gnomAD missense Z

0.84

DepMap mean gene effect

0.18

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• neuron projection development
• peptidyl-serine phosphorylation
• positive regulation of translational initiation
• regulation of cell cycle
• regulation of protein export from nucleus

Molecular functions

• ATP binding
• protein serine kinase activity
• protein serine/threonine kinase activity
• ribonucleoprotein complex binding
• RNA binding

Cellular components

• axon
• dendrite cytoplasm
• neuronal ribonucleoprotein granule
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• RNA recognition motif domain
• Protein kinase domain
• Protein kinase-like domain superfamily
• Nucleotide-binding alpha-beta plait domain superfamily
• RNA-binding domain superfamily
• Protein kinase domain
• RNA recognition motif
• Serine/threonine-protein kinase Kist

KeywordsUniProt

• ATP-binding
• Kinase
• Nucleotide-binding
• Nucleus
• RNA-binding
• Serine/threonine-protein kinase
• Transferase

InteractionsUniProt · HPA

Protein binding partners of UHMK1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PAM
• CDKN1B