Seroatlas · Human Serome Atlas

TRA2B

Transformer-2 protein homolog beta

Also known as: Htra2-beta, PPP1R156, SFRS10, TRA2B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P62995
Gene
TRA2B
Ensembl
ENSG00000136527
Chromosome
3
Canonical length
288 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a nuclear protein which functions as sequence-specific serine/arginine splicing factor which plays a role in mRNA processing, splicing patterns, and gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

288 residues, UniProt reviewed canonical sequence.

>P62995|TRA2B
     1  MSDSGEQNYG ERESRSASRS GSAHGSGKSA RHTPARSRSK EDSRRSRSKS RSRSESRSRS
    61  RRSSRRHYTR SRSRSRSHRR SRSRSYSRDY RRRHSHSHSP MSTRRRHVGN RANPDPNCCL
   121  GVFGLSLYTT ERDLREVFSK YGPIADVSIV YDQQSRRSRG FAFVYFENVD DAKEAKERAN
   181  GMELDGRRIR VDFSITKRPH TPTPGIYMGR PTYGSSRRRD YYDRGYDRGY DDRDYYSRSY
   241  RGGGGGGGGW RAAQDRDQIY RRRSPSPYYS RGGYRSRSRS RSYSPRRY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRA2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 44 nTPM
  • bone marrow: 44 nTPM
  • tonsil: 41 nTPM
  • lymph node: 36 nTPM
  • appendix: 33 nTPM
  • adrenal gland: 32 nTPM

Single-cell type

  • monocyte progenitors: 604 nCPM
  • neutrophil progenitors: 574 nCPM
  • kupffer cells: 466 nCPM
  • epididymal efferent duct absorptive cells: 428 nCPM
  • monocytes: 397 nCPM
  • macrophages: 376 nCPM

Immune cell

  • non-classical monocyte: 32 nTPM
  • myeloid DC: 31 nTPM
  • NK-cell: 28 nTPM
  • T-reg: 25 nTPM
  • intermediate monocyte: 24 nTPM
  • total PBMC: 21 nTPM

Brain region

  • cerebellum: 21 nTPM
  • cerebral cortex: 20 nTPM
  • white matter: 17 nTPM
  • hypothalamus: 16 nTPM
  • pons: 15 nTPM
  • medulla oblongata: 14 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TRA2B.

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 45 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Ramond-Elliott neurodevelopmental syndrome
  • TRA2B-associated epileptic encephalopathy
  • TRA2B-related condition

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.25
gnomAD pLI
0.99
gnomAD missense Z
3.5
DepMap mean gene effect
-0.5
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRA2B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRA2B as an antibody target. Whether an autoantibody or antibody against TRA2B could matter depends on whether native TRA2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRA2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRA2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRA2B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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