Seroatlas · Human Serome Atlas

AKAP17A

A-kinase anchor protein 17A

Also known as: 721P, AK17A_HUMAN, CCDC133, CXYorf3, DXYS155E, MGC39904, SFRS17A, XE7, XE7Y

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q02040
Gene
AKAP17A
Ensembl
ENSG00000197976
Chromosome
X
Canonical length
695 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear speckles,Cytosol

OverviewNCBI Gene

This locus encodes a protein kinase A anchoring protein. The encoded protein is part of the spliceosome complex and is involved in the regulation of alternate splicing in some mRNA precursors. Alternatively spliced transcript variants have been identified for this gene.[provided by RefSeq, Sep 2010]

Canonical amino-acid sequenceUniProt

695 residues, UniProt reviewed canonical sequence.

>Q02040|AKAP17A
     1  MAAATIVHDT SEAVELCPAY GLYLKPITKM TISVALPQLK QPGKSISNWE VMERLKGMVQ
    61  NHQFSTLRIS KSTMDFIRFE GEVENKSLVK SFLACLDGKT IKLSGFSDIL KVRAAEFKID
   121  FPTRHDWDSF FRDAKDMNET LPGERPDTIH LEGLPCKWFA LKESGSEKPS EDVLVKVFEK
   181  FGEIRNVDIP MLDPYREEMT GRNFHTFSFG GHLNFEAYVQ YREYMGFIQA MSALRGMKLM
   241  YKGEDGKAVA CNIKVSFDST KHLSDASIKK RQLERQKLQE LEQQREEQKR REKEAEERQR
   301  AEERKQKELE ELERERKREE KLRKREQKQR DRELRRNQKK LEKLQAEEQK QLQEKIKLEE
   361  RKLLLAQRNL QSIRLIAELL SRAKAVKLRE QEQKEEKLRL QQQEERRRLQ EAELRRVEEE
   421  KERALGLQRK ERELRERLLS ILLSKKPDDS HTHDELGVAH ADLLQPVLDI LQTVSSGCVS
   481  ATTLHPLGGQ PPAGAPKESP AHPEADGAPK SVNGSVAEEA PCKEVQSSCR VVPEDGSPEK
   541  RCPGGVLSCI PDNNQQPKGI PACEQNVSRK DTRSEQDKCN REPSKGRGRA TGDGLADRHK
   601  RERSRARRAS SREDGRPRKE RRPHKKHAYK DDSPRRRSTS PDHTRSRRSH SKDRHRRERS
   661  RERRGSASRK HSRHRRRSER SRSRSPSRHR STWNR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AKAP17A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
82 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 82 nTPM
  • ovary: 72 nTPM
  • liver: 70 nTPM
  • pancreas: 67 nTPM
  • thyroid gland: 62 nTPM
  • lung: 51 nTPM

Single-cell type

  • epididymal principal cells: 114 nCPM
  • syncytiotrophoblasts: 101 nCPM
  • neutrophils: 89 nCPM
  • innate lymphoid cells: 75 nCPM
  • plasma cells: 65 nCPM
  • pdcs: 62 nCPM

Immune cell

  • basophil: 4.5 nTPM
  • neutrophil: 1.9 nTPM
  • eosinophil: 0.9 nTPM
  • memory B-cell: 0.9 nTPM
  • plasmacytoid DC: 0.8 nTPM
  • memory CD8 T-cell: 0.7 nTPM

Brain region

  • white matter: 38 nTPM
  • cerebral cortex: 31 nTPM
  • medulla oblongata: 31 nTPM
  • thalamus: 30 nTPM
  • choroid plexus: 28 nTPM
  • basal ganglia: 27 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about AKAP17A.

Disease | ImmuneIEDB

Conditions an epitope on AKAP17A was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.52
gnomAD pLI
0.5
gnomAD missense Z
0.28

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AKAP17A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AKAP17A as an antibody target. Whether an autoantibody or antibody against AKAP17A could matter depends on whether native AKAP17A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AKAP17A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AKAP17A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AKAP17A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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