RBM47

Protein identityUniProt · HPA

UniProt accession

A0AV96

Gene

RBM47

Ensembl

ENSG00000163694

Chromosome

4

Canonical length

593 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

Quaternary structure

Homodimer

OverviewNCBI Gene

Enables enzyme binding activity; enzyme-substrate adaptor activity; and mRNA 3'-UTR binding activity. Involved in cytidine to uridine editing; positive regulation of type I interferon-mediated signaling pathway; and regulation of mRNA metabolic process. Located in cytoplasm and nucleus. Part of apolipoprotein B mRNA editing enzyme complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

593 residues, UniProt reviewed canonical sequence.

>A0AV96|RBM47
     1  MTAEDSTAAM SSDSAAGSSA KVPEGVAGAP NEAALLALME RTGYSMVQEN GQRKYGGPPP
    61  GWEGPHPQRG CEVFVGKIPR DVYEDELVPV FEAVGRIYEL RLMMDFDGKN RGYAFVMYCH
   121  KHEAKRAVRE LNNYEIRPGR LLGVCCSVDN CRLFIGGIPK MKKREEILEE IAKVTEGVLD
   181  VIVYASAADK MKNRGFAFVE YESHRAAAMA RRKLMPGRIQ LWGHQIAVDW AEPEIDVDED
   241  VMETVKILYV RNLMIETTED TIKKSFGQFN PGCVERVKKI RDYAFVHFTS REDAVHAMNN
   301  LNGTELEGSC LEVTLAKPVD KEQYSRYQKA ARGGGAAEAA QQPSYVYSCD PYTLAYYGYP
   361  YNALIGPNRD YFVKAGSIRG RGRGAAGNRA PGPRGSYLGG YSAGRGIYSR YHEGKGKQQE
   421  KGYELVPNLE IPTVNPVAIK PGTVAIPAIG AQYSMFPAAP APKMIEDGKI HTVEHMISPI
   481  AVQPDPASAA AAAAAAAAAA AAVIPTVSTP PPFQGRPITP VYTVAPNVQR IPTAGIYGAS
   541  YVPFAAPATA TIATLQKNAA AAAAMYGGYA GYIPQAFPAA AIQVPIPDVY QTY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBM47 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.5

Highest tissue expression

64 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.29

gnomAD pLI

0.98

gnomAD missense Z

2.59

DepMap mean gene effect

-0.01

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• 3'-UTR-mediated mRNA stabilization
• cytidine to uridine editing
• hematopoietic progenitor cell differentiation
• mRNA processing
• positive regulation of interleukin-10 production
• positive regulation of type I interferon-mediated signaling pathway
• regulation of alternative mRNA splicing, via spliceosome
• RNA splicing

Molecular functions

• enzyme binding
• enzyme-substrate adaptor activity
• mRNA 3'-UTR binding
• mRNA binding
• RNA binding

Cellular components

• apolipoprotein B mRNA editing enzyme complex
• cytoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• RNA recognition motif domain
• HnRNP R/Q splicing factor
• Nucleotide-binding alpha-beta plait domain superfamily
• RNA-binding domain superfamily
• RNA recognition motif
• RNA-binding protein 47, RNA recognition motif 2
• RNA-binding protein 47, RNA recognition motif 3
• RNA-binding protein 47, RNA recognition motif 1

KeywordsUniProt

• Cytoplasm
• Methylation
• mRNA processing
• mRNA splicing
• Nucleus
• Repeat
• RNA-binding

InteractionsUniProt · HPA

Protein binding partners of RBM47 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• A1CF
• APOBEC1
• RBPMS