Seroatlas · Human Serome Atlas

HNRNPLL

Heterogeneous nuclear ribonucleoprotein L-like

Also known as: HNRLL_HUMAN, HNRPLL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WVV9
Gene
HNRNPLL
Ensembl
ENSG00000143889
Chromosome
2
Canonical length
542 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Mitochondria,Cytosol

OverviewNCBI Gene

HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).[supplied by OMIM, Aug 2008]

Canonical amino-acid sequenceUniProt

542 residues, UniProt reviewed canonical sequence.

>Q8WVV9|HNRNPLL
     1  MSSSSSSPRE TYEEDREYES QAKRLKTEEG EIDYSAEEGE NRREATPRGG GDGGGGGRSF
    61  SQPEAGGSHH KVSVSPVVHV RGLCESVVEA DLVEALEKFG TICYVMMMPF KRQALVEFEN
   121  IDSAKECVTF AADEPVYIAG QQAFFNYSTS KRITRPGNTD DPSGGNKVLL LSIQNPLYPI
   181  TVDVLYTVCN PVGKVQRIVI FKRNGIQAMV EFESVLCAQK AKAALNGADI YAGCCTLKIE
   241  YARPTRLNVI RNDNDSWDYT KPYLGRRDRG KGRQRQAILG EHPSSFRHDG YGSHGPLLPL
   301  PSRYRMGSRD TPELVAYPLP QASSSYMHGG NPSGSVVMVS GLHQLKMNCS RVFNLFCLYG
   361  NIEKVKFMKT IPGTALVEMG DEYAVERAVT HLNNVKLFGK RLNVCVSKQH SVVPSQIFEL
   421  EDGTSSYKDF AMSKNNRFTS AGQASKNIIQ PPSCVLHYYN VPLCVTEETF TKLCNDHEVL
   481  TFIKYKVFDA KPSAKTLSGL LEWECKTDAV EALTALNHYQ IRVPNGSNPY TLKLCFSTSS
   541  HL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HNRNPLL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
49 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 49 nTPM
  • thymus: 29 nTPM
  • retina: 25 nTPM
  • testis: 21 nTPM
  • blood vessel: 19 nTPM
  • thyroid gland: 17 nTPM

Single-cell type

  • neutrophil progenitors: 530 nCPM
  • pituicytes/fscs: 310 nCPM
  • late primary spermatocytes: 223 nCPM
  • t-cells: 140 nCPM
  • early spermatids: 135 nCPM
  • platelets: 134 nCPM

Immune cell

  • T-reg: 39 nTPM
  • memory CD4 T-cell: 24 nTPM
  • memory CD8 T-cell: 19 nTPM
  • MAIT T-cell: 18 nTPM
  • myeloid DC: 12 nTPM
  • basophil: 11 nTPM

Brain region

  • hippocampal formation: 82 nTPM
  • cerebral cortex: 66 nTPM
  • basal ganglia: 64 nTPM
  • cerebellum: 62 nTPM
  • white matter: 55 nTPM
  • choroid plexus: 49 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HNRNPLL.

Disease | ImmuneIEDB

Conditions an epitope on HNRNPLL was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.35
gnomAD pLI
0.92
gnomAD missense Z
2.36
DepMap mean gene effect
-0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HNRNPLL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HNRNPLL as an antibody target. Whether an autoantibody or antibody against HNRNPLL could matter depends on whether native HNRNPLL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HNRNPLL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HNRNPLL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HNRNPLL. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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