Seroatlas · Human Serome Atlas

RBMX

RNA-binding motif protein, X chromosome

Also known as: hnRNP-G, HNRNPG, RBMX_HUMAN, RNMX

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P38159
Gene
RBMX
Ensembl
ENSG00000147274
Chromosome
X
Canonical length
391 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm
Quaternary structure
Homomultimer

OverviewNCBI Gene

This gene belongs to the RBMY gene family which includes candidate Y chromosome spermatogenesis genes. This gene, an active X chromosome homolog of the Y chromosome RBMY gene, is widely expressed whereas the RBMY gene evolved a male-specific function in spermatogenesis. Pseudogenes of this gene, found on chromosomes 1, 4, 9, 11, and 6, were likely derived by retrotransposition from the original gene. Alternatively spliced transcript variants encoding different isoforms have been identified. A snoRNA gene (SNORD61) is found in one of its introns. [provided by RefSeq, Sep 2009]

Canonical amino-acid sequenceUniProt

391 residues, UniProt reviewed canonical sequence.

>P38159|RBMX
     1  MVEADRPGKL FIGGLNTETN EKALEAVFGK YGRIVEVLLM KDRETNKSRG FAFVTFESPA
    61  DAKDAARDMN GKSLDGKAIK VEQATKPSFE SGRRGPPPPP RSRGPPRGLR GGRGGSGGTR
   121  GPPSRGGHMD DGGYSMNFNM SSSRGPLPVK RGPPPRSGGP PPKRSAPSGP VRSSSGMGGR
   181  APVSRGRDSY GGPPRREPLP SRRDVYLSPR DDGYSTKDSY SSRDYPSSRD TRDYAPPPRD
   241  YTYRDYGHSS SRDDYPSRGY SDRDGYGRDR DYSDHPSGGS YRDSYESYGN SRSAPPTRGP
   301  PPSYGGSSRY DDYSSSRDGY GGSRDSYSSS RSDLYSSGRD RVGRQERGLP PSMERGYPPP
   361  RDSYSSSSRG APRGGGRGGS RSDRGGGRSR Y

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBMX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
218 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 218 nTPM
  • thymus: 196 nTPM
  • bone marrow: 163 nTPM
  • tonsil: 136 nTPM
  • endometrium: 133 nTPM
  • skeletal muscle: 120 nTPM

Single-cell type

  • epididymal basal cells: 362 nCPM
  • myonuclei: 358 nCPM
  • tuft cells: 357 nCPM
  • extravillous trophoblasts: 353 nCPM
  • erythrocyte progenitors: 352 nCPM
  • pituicytes/fscs: 334 nCPM

Immune cell

  • total PBMC: 303 nTPM
  • naive CD4 T-cell: 233 nTPM
  • T-reg: 204 nTPM
  • MAIT T-cell: 200 nTPM
  • memory B-cell: 195 nTPM
  • naive CD8 T-cell: 193 nTPM

Brain region

  • white matter: 86 nTPM
  • medulla oblongata: 68 nTPM
  • cerebellum: 65 nTPM
  • spinal cord: 63 nTPM
  • basal ganglia: 62 nTPM
  • pons: 60 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RBMX.

Disease | AllUniProt

Conditions RBMX is implicated in, by any mechanism.

  • Intellectual developmental disorder, X-linked, syndromic, Shashi type (MRXSSH) MIM:300238
  • Intellectual developmental disorder, X-linked, syndromic, Gustavson type (MRXSG) MIM:309555

Disease | GeneticClinVar

11 pathogenic / likely-pathogenic of 136 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • RBMX-related disorder
  • Severe X-linked intellectual disability, Gustavson type
  • Syndromic X-linked intellectual disability Shashi type

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.43
gnomAD pLI
0.83
gnomAD missense Z
2.9
DepMap mean gene effect
-1.76
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RBMX in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBMX as an antibody target. Whether an autoantibody or antibody against RBMX could matter depends on whether native RBMX is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBMX is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBMX as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RBMX. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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