TNRC6B

Protein identityUniProt · HPA

UniProt accession

Q9UPQ9

Gene

TNRC6B

Ensembl

ENSG00000100354

Chromosome

22

Canonical length

1833 aa

Protein class

Disease related genes, Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

Enables RNA binding activity. Involved in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; and regulatory ncRNA-mediated gene silencing. Acts upstream of with a positive effect on miRNA-mediated gene silencing by inhibition of translation. Predicted to be located in cytosol. Predicted to be active in P-body and nucleoplasm. Implicated in subserous uterine fibroid and uterine fibroid. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1833 residues, UniProt reviewed canonical sequence.

>Q9UPQ9|TNRC6B
     1  MREKEQEREE QLMEDKKRKK EDKKKKEATQ KVTEQKTKVP EVTKPSLSQP TAASPIGSSP
    61  SPPVNGGNNA KRVAVPNGQP PSAARYMPRE VPPRFRCQQD HKVLLKRGQP PPPSCMLLGG
   121  GAGPPPCTAP GANPNNAQVT GALLQSESGT APDSTLGGAA ASNYANSTWG SGASSNNGTS
   181  PNPIHIWDKV IVDGSDMEEW PCIASKDTES SSENTTDNNS ASNPGSEKST LPGSTTSNKG
   241  KGSQCQSASS GNECNLGVWK SDPKAKSVQS SNSTTENNNG LGNWRNVSGQ DRIGPGSGFS
   301  NFNPNSNPSA WPALVQEGTS RKGALETDNS NSSAQVSTVG QTSREQQSKM ENAGVNFVVS
   361  GREQAQIHNT DGPKNGNTNS LNLSSPNPME NKGMPFGMGL GNTSRSTDAP SQSTGDRKTG
   421  SVGSWGAARG PSGTDTVSGQ SNSGNNGNNG KEREDSWKGA SVQKSTGSKN DSWDNNNRST
   481  GGSWNFGPQD SNDNKWGEGN KMTSGVSQGE WKQPTGSDEL KIGEWSGPNQ PNSSTGAWDN
   541  QKGHPLPENQ GNAQAPCWGR SSSSTGSEVG GQSTGSNHKA GSSDSHNSGR RSYRPTHPDC
   601  QAVLQTLLSR TDLDPRVLSN TGWGQTQIKQ DTVWDIEEVP RPEGKSDKGT EGWESAATQT
   661  KNSGGWGDAP SQSNQMKSGW GELSASTEWK DPKNTGGWND YKNNNSSNWG GGRPDEKTPS
   721  SWNENPSKDQ GWGGGRQPNQ GWSSGKNGWG EEVDQTKNSN WESSASKPVS GWGEGGQNEI
   781  GTWGNGGNAS LASKGGWEDC KRSPAWNETG RQPNSWNKQH QQQQPPQQPP PPQPEASGSW
   841  GGPPPPPPGN VRPSNSSWSS GPQPATPKDE EPSGWEEPSP QSISRKMDID DGTSAWGDPN
   901  SYNYKNVNLW DKNSQGGPAP REPNLPTPMT SKSASVWSKS TPPAPDNGTS AWGEPNESSP
   961  GWGEMDDTGA STTGWGNTPA NAPNAMKPNS KSMQDGWGES DGPVTGARHP SWEEEEDGGV
  1021  WNTTGSQGSA SSHNSASWGQ GGKKQMKCSL KGGNNDSWMN PLAKQFSNMG LLSQTEDNPS
  1081  SKMDLSVGSL SDKKFDVDKR AMNLGDFNDI MRKDRSGFRP PNSKDMGTTD SGPYFEKLTL
  1141  PFSNQDGCLG DEAPCSPFSP SPSYKLSPSG STLPNVSLGA IGTGLNPQNF AARQGGSHGL
  1201  FGNSTAQSRG LHTPVQPLNS SPSLRAQVPP QFISPQVSAS MLKQFPNSGL SPGLFNVGPQ
  1261  LSPQQIAMLS QLPQIPQFQL ACQLLLQQQQ QQQLLQNQRK ISQAVRQQQE QQLARMVSAL
  1321  QQQQQQQQRQ PGMKHSPSHP VGPKPHLDNM VPNALNVGLP DLQTKGPIPG YGSGFSSGGM
  1381  DYGMVGGKEA GTESRFKQWT SMMEGLPSVA TQEANMHKNG AIVAPGKTRG GSPYNQFDII
  1441  PGDTLGGHTG PAGDSWLPAK SPPTNKIGSK SSNASWPPEF QPGVPWKGIQ NIDPESDPYV
  1501  TPGSVLGGTA TSPIVDTDHQ LLRDNTTGSN SSLNTSLPSP GAWPYSASDN SFTNVHSTSA
  1561  KFPDYKSTWS PDPIGHNPTH LSNKMWKNHI SSRNTTPLPR PPPGLTNPKP SSPWSSTAPR
  1621  SVRGWGTQDS RLASASTWSD GGSVRPSYWL VLHNLTPQID GSTLRTICMQ HGPLLTFHLN
  1681  LTQGTALIRY STKQEAAKAQ TALHMCVLGN TTILAEFATD DEVSRFLAQA QPPTPAATPS
  1741  APAAGWQSLE TGQNQSDPVG PALNLFGGST GLGQWSSSAG GSSGADLAGA SLWGPPNYSS
  1801  SLWGVPTVED PHRMGSPAPL LPGDLLGGGS DSI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNRC6B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.67

Highest tissue expression

18 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TNRC6B.

Disease | AllUniProt

Conditions TNRC6B is implicated in, by any mechanism.

• Global developmental delay with speech and behavioral abnormalities (GDSBA) MIM:619243

Disease | GeneticClinVar

71 pathogenic / likely-pathogenic of 641 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Global developmental delay with speech and behavioral abnormalities
• Inborn genetic diseases
• TNRC6B-related disorder
• Neurodevelopmental delay
• Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.17

gnomAD pLI

1

gnomAD missense Z

2.87

DepMap mean gene effect

-0.07

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• miRNA-mediated gene silencing by inhibition of translation
• miRNA-mediated post-transcriptional gene silencing
• positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
• positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
• regulatory ncRNA-mediated gene silencing

Molecular functions

• RNA binding

Cellular components

• cytosol
• nucleoplasm
• P-body

Protein domainsUniProt · Pfam · InterPro

• Nucleotide-binding alpha-beta plait domain superfamily
• Argonaute hook domain
• TNRC6, PABC binding domain
• RNA-binding domain superfamily
• GW182 domain-containing protein
• Argonaute hook
• TNRC6-PABC binding domain
• TNRC6B, RNA recognition motif

KeywordsUniProt

• Autism spectrum disorder
• Coiled coil
• Cytoplasm
• Intellectual disability
• Phosphoprotein
• RNA-binding
• RNA-mediated gene silencing
• Translation regulation

InteractionsUniProt · HPA

Protein binding partners of TNRC6B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• AGO1
• AGO2
• AGO3
• AGO4
• CNOT1
• MOV10
• PAN3
• DCP1B
• PABPC1