CPEB3
Cytoplasmic polyadenylation element-binding protein 3
Also known as: CPEB3_HUMAN, KIAA0940
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8NE35
- Gene
- CPEB3
- Ensembl
- ENSG00000107864
- Chromosome
- 10
- Canonical length
- 698 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Plasma membrane,Midbody,Cytosol
OverviewNCBI Gene
Enables mRNA 3'-UTR binding activity and translation factor activity, RNA binding. Involved in cellular response to amino acid stimulus and regulation of gene expression. Located in several cellular components, including cytosol; midbody; and nucleoplasm. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
698 residues, UniProt reviewed canonical sequence.
>Q8NE35|CPEB3
1 MQDDLLMDKS KTQPQPQQQQ RQQQQPQPES SVSEAPSTPL SSETPKPEEN SAVPALSPAA
61 APPAPNGPDK MQMESPLLPG LSFHQPPQQP PPPQEPAAPG ASLSPSFGST WSTGTTNAVE
121 DSFFQGITPV NGTMLFQNFP HHVNPVFGGT FSPQIGLAQT QHHQQPPPPA PAPQPAQPAQ
181 PPQAQPPQQR RSPASPSQAP YAQRSAAAAY GHQPIMTSKP SSSSAVAAAA AAAAASSASS
241 SWNTHQSVNA AWSAPSNPWG GLQAGRDPRR AVGVGVGVGV GVPSPLNPIS PLKKPFSSNV
301 IAPPKFPRAA PLTSKSWMED NAFRTDNGNN LLPFQDRSRP YDTFNLHSLE NSLMDMIRTD
361 HEPLKGKHYP PSGPPMSFAD IMWRNHFAGR MGINFHHPGT DNIMALNNAF LDDSHGDQAL
421 SSGLSSPTRC QNGERVERYS RKVFVGGLPP DIDEDEITAS FRRFGPLVVD WPHKAESKSY
481 FPPKGYAFLL FQEESSVQAL IDACLEEDGK LYLCVSSPTI KDKPVQIRPW NLSDSDFVMD
541 GSQPLDPRKT IFVGGVPRPL RAVELAMIMD RLYGGVCYAG IDTDPELKYP KGAGRVAFSN
601 QQSYIAAISA RFVQLQHNDI DKRVEVKPYV LDDQMCDECQ GTRCGGKFAP FFCANVTCLQ
661 YYCEYCWASI HSRAGREFHK PLVKEGGDRP RHVPFRWSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CPEB3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.57
- Highest tissue expression
- 30 nTPM
Expression across tissuesHPA
Tissue
- liver: 30 nTPM
- skeletal muscle: 18 nTPM
- cerebral cortex: 10 nTPM
- testis: 10 nTPM
- cerebellum: 10 nTPM
- tongue: 8.9 nTPM
Single-cell type
- late spermatids: 710 nCPM
- choroid plexus epithelial cells: 661 nCPM
- retinal ganglion cells: 649 nCPM
- distal convoluted tubule cells: 497 nCPM
- cone photoreceptor cells: 495 nCPM
- loop of henle epithelial cells: 468 nCPM
Immune cell
- basophil: 2.6 nTPM
- eosinophil: 0.8 nTPM
- memory B-cell: 0.7 nTPM
- non-classical monocyte: 0.6 nTPM
- intermediate monocyte: 0.5 nTPM
- neutrophil: 0.5 nTPM
Brain region
- cerebral cortex: 58 nTPM
- pons: 45 nTPM
- white matter: 36 nTPM
- midbrain: 35 nTPM
- basal ganglia: 34 nTPM
- cerebellum: 34 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.23
- gnomAD pLI
- 1
- gnomAD missense Z
- 2.56
- DepMap mean gene effect
- 0.01
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- 3'-UTR-mediated mRNA destabilization
- cellular response to amino acid stimulus
- long-term memory
- negative regulation of cytoplasmic translation
- negative regulation of cytoplasmic translational elongation
- negative regulation of transcription by RNA polymerase II
- negative regulation of translation
- positive regulation of dendritic spine development
- positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
- positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
- positive regulation of translation
- regulation of dendritic spine development
- regulation of postsynapse assembly
- regulation of synaptic plasticity
Molecular functions
- mRNA 3'-UTR AU-rich region binding
- mRNA 3'-UTR binding
- mRNA regulatory element binding translation repressor activity
- ribosome binding
- RNA binding
- RNA stem-loop binding
- translation factor activity, RNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
- RNA recognition motif domain
- Nucleotide-binding alpha-beta plait domain superfamily
- Cytoplasmic polyadenylation element-binding protein, ZZ domain
- Cytoplasmic polyadenylation element-binding protein
- RNA-binding domain superfamily
- CEBP, ZZ domain superfamily
- Cytoplasmic polyadenylation element-binding protein ZZ domain
- RNA recognition motif
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CPEB3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CPEB3 as an antibody target. Whether an autoantibody or antibody against CPEB3 could matter depends on whether native CPEB3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CPEB3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CPEB3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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