Seroatlas · Human Serome Atlas

HNRNPC

Heterogeneous nuclear ribonucleoproteins C1/C2

Also known as: HNRPC, HNRPC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P07910
Gene
HNRNPC
Ensembl
ENSG00000092199
Chromosome
14
Canonical length
306 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

306 residues, UniProt reviewed canonical sequence.

>P07910|HNRNPC
     1  MASNVTNKTD PRSMNSRVFI GNLNTLVVKK SDVEAIFSKY GKIVGCSVHK GFAFVQYVNE
    61  RNARAAVAGE DGRMIAGQVL DINLAAEPKV NRGKAGVKRS AAEMYGSVTE HPSPSPLLSS
   121  SFDLDYDFQR DYYDRMYSYP ARVPPPPPIA RAVVPSKRQR VSGNTSRRGK SGFNSKSGQR
   181  GSSKSGKLKG DDLQAIKKEL TQIKQKVDSL LENLEKIEKE QSKQAVEMKN DKSEEEQSSS
   241  SVKKDETNVK MESEGGADDS AEEGDLLDDD DNEDRGDDQL ELIKDDEKEA EEGEDDRDSA
   301  NGEDDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HNRNPC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
520 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 520 nTPM
  • bone marrow: 511 nTPM
  • lymph node: 466 nTPM
  • tonsil: 465 nTPM
  • ovary: 415 nTPM
  • retina: 382 nTPM

Single-cell type

  • neutrophils: 1,730 nCPM
  • endometrial glandular cells: 1,307 nCPM
  • monocytes: 1,007 nCPM
  • syncytiotrophoblasts: 944 nCPM
  • endometrial luminal cells: 924 nCPM
  • endometrial secretory cells: 825 nCPM

Immune cell

  • total PBMC: 1,222 nTPM
  • neutrophil: 815 nTPM
  • myeloid DC: 718 nTPM
  • T-reg: 578 nTPM
  • naive CD4 T-cell: 555 nTPM
  • MAIT T-cell: 547 nTPM

Brain region

  • white matter: 364 nTPM
  • medulla oblongata: 316 nTPM
  • spinal cord: 313 nTPM
  • hypothalamus: 301 nTPM
  • pons: 300 nTPM
  • cerebral cortex: 294 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HNRNPC.

Disease | AllUniProt

Conditions HNRNPC is implicated in, by any mechanism.

  • Intellectual developmental disorder, autosomal dominant 74 (MRD74) MIM:620688

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 68 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Intellectual developmental disorder, autosomal dominant 74

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.3
gnomAD pLI
0.98
gnomAD missense Z
2.89
DepMap mean gene effect
-1.03
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HNRNPC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HNRNPC as an antibody target. Whether an autoantibody or antibody against HNRNPC could matter depends on whether native HNRNPC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HNRNPC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HNRNPC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HNRNPC. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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