Seroatlas · Human Serome Atlas

ACIN1

Apoptotic chromatin condensation inducer in the nucleus

Also known as: ACINU_HUMAN, ACINUS, fSAP152, KIAA0670

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UKV3
Gene: ACIN1
Ensembl: ENSG00000100813
Chromosome: 14
Canonical length: 1341 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

1341 residues, UniProt reviewed canonical sequence.

>Q9UKV3|ACIN1
     1  MWRRKHPRTS GGTRGVLSGN RGVEYGSGRG HLGTFEGRWR KLPKMPEAVG TDPSTSRKMA
    61  ELEEVTLDGK PLQALRVTDL KAALEQRGLA KSGQKSALVK RLKGALMLEN LQKHSTPHAA
   121  FQPNSQIGEE MSQNSFIKQY LEKQQELLRQ RLEREAREAA ELEEASAESE DEMIHPEGVA
   181  SLLPPDFQSS LERPELELSR HSPRKSSSIS EEKGDSDDEK PRKGERRSSR VRQARAAKLS
   241  EGSQPAEEEE DQETPSRNLR VRADRNLKTE EEEEEEEEEE EDDEEEEGDD EGQKSREAPI
   301  LKEFKEEGEE IPRVKPEEMM DERPKTRSQE QEVLERGGRF TRSQEEARKS HLARQQQEKE
   361  MKTTSPLEEE EREIKSSQGL KEKSKSPSPP RLTEDRKKAS LVALPEQTAS EEETPPPLLT
   421  KEASSPPPHP QLHSEEEIEP MEGPAPAVLI QLSPPNTDAD TRELLVSQHT VQLVGGLSPL
   481  SSPSDTKAES PAEKVPEESV LPLVQKSTLA DYSAQKDLEP ESDRSAQPLP LKIEELALAK
   541  GITEECLKQP SLEQKEGRRA SHTLLPSHRL KQSADSSSSR SSSSSSSSSR SRSRSPDSSG
   601  SRSHSPLRSK QRDVAQARTH ANPRGRPKMG SRSTSESRSR SRSRSRSASS NSRKSLSPGV
   661  SRDSSTSYTE TKDPSSGQEV ATPPVPQLQV CEPKERTSTS SSSVQARRLS QPESAEKHVT
   721  QRLQPERGSP KKCEAEEAEP PAATQPQTSE TQTSHLPESE RIHHTVEEKE EVTMDTSENR
   781  PENDVPEPPM PIADQVSNDD RPEGSVEDEE KKESSLPKSF KRKISVVSAT KGVPAGNSDT
   841  EGGQPGRKRR WGASTATTQK KPSISITTES LKSLIPDIKP LAGQEAVVDL HADDSRISED
   901  ETERNGDDGT HDKGLKICRT VTQVVPAEGQ ENGQREEEEE EKEPEAEPPV PPQVSVEVAL
   961  PPPAEHEVKK VTLGDTLTRR SISQQKSGVS ITIDDPVRTA QVPSPPRGKI SNIVHISNLV
  1021  RPFTLGQLKE LLGRTGTLVE EAFWIDKIKS HCFVTYSTVE EAVATRTALH GVKWPQSNPK
  1081  FLCADYAEQD ELDYHRGLLV DRPSETKTEE QGIPRPLHPP PPPPVQPPQH PRAEQREQER
  1141  AVREQWAERE REMERRERTR SEREWDRDKV REGPRSRSRS RDRRRKERAK SKEKKSEKKE
  1201  KAQEEPPAKL LDDLFRKTKA APCIYWLPLT DSQIVQKEAE RAERAKEREK RRKEQEEEEQ
  1261  KEREKEAERE RNRQLEREKR REHSRERDRE RERERERDRG DRDRDRERDR ERGRERDRRD
  1321  TKRHSRSRSR STPVRDRGGR R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACIN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 64 nTPM

Expression across tissuesHPA

Tissue

spleen: 64 nTPM
bone marrow: 63 nTPM
adrenal gland: 56 nTPM
skeletal muscle: 51 nTPM
esophagus: 50 nTPM
thymus: 49 nTPM

Single-cell type

neutrophils: 204 nCPM
adrenal cortex cells: 157 nCPM
endometrial glandular cells: 149 nCPM
neutrophil progenitors: 146 nCPM
syncytiotrophoblasts: 134 nCPM
endometrial ciliated cells: 133 nCPM

Immune cell

neutrophil: 11 nTPM
NK-cell: 7.7 nTPM
plasmacytoid DC: 5.5 nTPM
basophil: 5.4 nTPM
naive B-cell: 5.4 nTPM
eosinophil: 5.1 nTPM

Brain region

cerebellum: 55 nTPM
white matter: 55 nTPM
hypothalamus: 54 nTPM
choroid plexus: 53 nTPM
thalamus: 52 nTPM
cerebral cortex: 51 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.2
gnomAD pLI: 1
gnomAD missense Z: 2.2
DepMap mean gene effect: -0.68
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

SAP domain
Nucleotide-binding alpha-beta plait domain superfamily
RNA-binding domain superfamily
SAP domain superfamily
SAP domain
Acin1, RNSP1-SAP18 binding (RSB) motif
Acinus, RNA recognition motif
Exon junction complex-associated protein
RNSP1-SAP18 binding (RSB) motif

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ACIN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACIN1 as an antibody target. Whether an autoantibody or antibody against ACIN1 could matter depends on whether native ACIN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACIN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACIN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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