Seroatlas · Human Serome Atlas

LARP6

La-related protein 6

Also known as: acheron, FLJ11196, LARP6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BRS8
Gene
LARP6
Ensembl
ENSG00000166173
Chromosome
15
Canonical length
491 aa
Protein class
Predicted intracellular proteins
Subcellular location
Microtubules,Cytokinetic bridge

OverviewNCBI Gene

Enables RNA binding activity and myosin binding activity. Involved in positive regulation of collagen biosynthetic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

491 residues, UniProt reviewed canonical sequence.

>Q9BRS8|LARP6
     1  MAQSGGEARP GPKTAVQIRV AIQEAEDVDE LEDEEEGAET RGAGDPARYL SPGWGSASEE
    61  EPSRGHSGTT ASGGENERED LEQEWKPPDE ELIKKLVDQI EFYFSDENLE KDAFLLKHVR
   121  RNKLGYVSVK LLTSFKKVKH LTRDWRTTAH ALKYSVVLEL NEDHRKVRRT TPVPLFPNEN
   181  LPSKMLLVYD LYLSPKLWAL ATPQKNGRVQ EKVMEHLLKL FGTFGVISSV RILKPGRELP
   241  PDIRRISSRY SQVGTQECAI VEFEEVEAAI KAHEFMITES QGKENMKAVL IGMKPPKKKP
   301  AKDKNHDEEP TASIHLNKSL NKRVEELQYM GDESSANSSS DPESNPTSPM AGRRHAATNK
   361  LSPSGHQNLF LSPNASPCTS PWSSPLAQRK GVSRKSPLAE EGRLNCSTSP EIFRKCMDYS
   421  SDSSVTPSGS PWVRRRRQAE MGTQEKSPGT SPLLSRKMQT ADGLPVGVLR LPRGPDNTRG
   481  FHGHERSRAC V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LARP6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
124 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 124 nTPM
  • midbrain: 86 nTPM
  • hippocampal formation: 83 nTPM
  • basal ganglia: 81 nTPM
  • amygdala: 57 nTPM
  • hypothalamus: 53 nTPM

Single-cell type

  • late primary spermatocytes: 481 nCPM
  • early spermatids: 365 nCPM
  • late spermatids: 328 nCPM
  • epididymal principal cells: 231 nCPM
  • oligodendrocytes: 142 nCPM
  • epididymal efferent duct ciliated cells: 141 nCPM

Immune cell

  • neutrophil: 0.3 nTPM
  • basophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • white matter: 158 nTPM
  • basal ganglia: 119 nTPM
  • medulla oblongata: 98 nTPM
  • cerebellum: 95 nTPM
  • cerebral cortex: 94 nTPM
  • midbrain: 94 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.51
gnomAD pLI
0.67
gnomAD missense Z
1.51
DepMap mean gene effect
-0.22
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LARP6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LARP6 as an antibody target. Whether an autoantibody or antibody against LARP6 could matter depends on whether native LARP6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LARP6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LARP6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LARP6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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