Seroatlas · Human Serome Atlas

RBM12B

RNA-binding protein 12B

Also known as: RB12B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IXT5
Gene: RBM12B
Ensembl: ENSG00000183808
Chromosome: 8
Canonical length: 1001 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1001 residues, UniProt reviewed canonical sequence.

>Q8IXT5|RBM12B
     1  MAVVIRLLGL PFIAGPVDIR HFFTGLTIPD GGVHIIGGEI GEAFIIFATD EDARRAISRS
    61  GGFIKDSSVE LFLSSKAEMQ KTIEMKRTDR VGRGRPGSGT SGVDSLSNFI ESVKEEASNS
   121  GYGSSINQDA GFHTNGTGHG NLRPRKTRPL KAENPYLFLR GLPYLVNEDD VRVFFSGLCV
   181  DGVIFLKHHD GRNNGDAIVK FASCVDASGG LKCHRSFMGS RFIEVMQGSE QQWIEFGGNA
   241  VKEGDVLRRS EEHSPPRGIN DRHFRKRSHS KSPRRTRSRS PLGFYVHLKN LSLSIDERDL
   301  RNFFRGTDLT DEQIRFLYKD ENRTRYAFVM FKTLKDYNTA LSLHKTVLQY RPVHIDPISR
   361  KQMLKFIARY EKKRSGSLER DRPGHVSQKY SQEGNSGQKL CIYIRNFPFD VTKVEVQKFF
   421  ADFLLAEDDI YLLYDDKGVG LGEALVKFKS EEQAMKAERL NRRRFLGTEV LLRLISEAQI
   481  QEFGVNFSVM SSEKMQARSQ SRERGDHSHL FDSKDPPIYS VGAFENFRHQ LEDLRQLDNF
   541  KHPQRDFRQP DRHPPEDFRH SSEDFRFPPE DFRHSPEDFR RPREEDFRRP SEEDFRRPWE
   601  EDFRRPPEDD FRHPREEDWR RPLEEDWRRP LEEDFRRSPT EDFRQLPEED FRQPPEEDLR
   661  WLPEEDFRRP PEEDWRRPPE EDFRRPLQGE WRRPPEDDFR RPPEEDFRHS PEEDFRQSPQ
   721  EHFRRPPQEH FRRPPPEHFR RPPPEHFRRP PPEHFRRPPP EHFRRPPPEH FRRPPPEHFR
   781  RPPQEHFRRP PQEHFRRSRE EDFRHPPDED FRGPPDEDFR HPPDEDFRSP QEEDFRCPSD
   841  EDFRQLPEED LREAPEEDPR LPDNFRPPGE DFRSPPDDFR SHRPFVNFGR PEGGKFDFGK
   901  HNMGSFPEGR FMPDPKINCG SGRVTPIKIM NLPFKANVNE ILDFFHGYRI IPDSVSIQYN
   961  EQGLPTGEAI VAMINYNEAM AAIKDLNDRP VGPRKVKLTL L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBM12B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 9.8 nTPM

Expression across tissuesHPA

Tissue

retina: 9.8 nTPM
ovary: 7.7 nTPM
lymph node: 7.6 nTPM
thymus: 6.8 nTPM
testis: 6.6 nTPM
thyroid gland: 6.3 nTPM

Single-cell type

myonuclei: 76 nCPM
corticotrophs: 69 nCPM
lactotrophs: 65 nCPM
thyrotrophs: 60 nCPM
somatotrophs: 60 nCPM
gonadotrophs: 55 nCPM

Immune cell

basophil: 4.3 nTPM
naive CD4 T-cell: 1.4 nTPM
MAIT T-cell: 1.2 nTPM
naive CD8 T-cell: 1.2 nTPM
T-reg: 1.2 nTPM
eosinophil: 1.1 nTPM

Brain region

cerebellum: 26 nTPM
white matter: 22 nTPM
choroid plexus: 19 nTPM
basal ganglia: 19 nTPM
cerebral cortex: 18 nTPM
midbrain: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.54
gnomAD pLI: 0
gnomAD missense Z: 0.86
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of RNA splicing

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

RNA recognition motif domain
Nucleotide-binding alpha-beta plait domain superfamily
RNA-binding domain superfamily
Epithelial Splicing Regulatory
RNA recognition motif
RBM12B, RNA recognition motif 2
RBM12B, RNA recognition motif 3
RNA-binding protein 12B, RNA recognition motif 4

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RBM12B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CACNA1A

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBM12B as an antibody target. Whether an autoantibody or antibody against RBM12B could matter depends on whether native RBM12B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBM12B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBM12B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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