Seroatlas · Human Serome Atlas

RBM4

RNA-binding protein 4

Also known as: LARK, RBM4_HUMAN, RBM4A, ZCCHC21, ZCRB3A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BWF3
Gene
RBM4
Ensembl
ENSG00000173933
Chromosome
11
Canonical length
364 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables RNA binding activity and cyclin binding activity. Involved in several processes, including IRES-dependent translational initiation of linear mRNA; negative regulation of translation; and regulation of alternative mRNA splicing, via spliceosome. Located in cytoplasmic stress granule; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

364 residues, UniProt reviewed canonical sequence.

>Q9BWF3|RBM4
     1  MVKLFIGNLP REATEQEIRS LFEQYGKVLE CDIIKNYGFV HIEDKTAAED AIRNLHHYKL
    61  HGVNINVEAS KNKSKTSTKL HVGNISPTCT NKELRAKFEE YGPVIECDIV KDYAFVHMER
   121  AEDAVEAIRG LDNTEFQGKR MHVQLSTSRL RTAPGMGDQS GCYRCGKEGH WSKECPIDRS
   181  GRVADLTEQY NEQYGAVRTP YTMSYGDSLY YNNAYGALDA YYKRCRAARS YEAVAAAAAS
   241  VYNYAEQTLS QLPQVQNTAM ASHLTSTSLD PYDRHLLPTS GAAATAAAAA AAAAAVTAAS
   301  TSYYGRDRSP LRRATAPVPT VGEGYGYGHE SELSQASAAA RNSLYDMARY EREQYADRAR
   361  YSAF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBM4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
124 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 124 nTPM
  • cerebellum: 118 nTPM
  • pancreas: 112 nTPM
  • adrenal gland: 109 nTPM
  • spleen: 106 nTPM
  • kidney: 106 nTPM

Single-cell type

  • myonuclei: 98 nCPM
  • cardiomyocytes: 96 nCPM
  • brain excitatory neurons: 92 nCPM
  • choroid plexus epithelial cells: 88 nCPM
  • other brain neurons: 86 nCPM
  • microglia: 84 nCPM

Immune cell

  • basophil: 211 nTPM
  • T-reg: 195 nTPM
  • total PBMC: 159 nTPM
  • NK-cell: 156 nTPM
  • naive CD8 T-cell: 150 nTPM
  • memory CD8 T-cell: 150 nTPM

Brain region

  • cerebellum: 120 nTPM
  • choroid plexus: 98 nTPM
  • hypothalamus: 97 nTPM
  • white matter: 86 nTPM
  • basal ganglia: 83 nTPM
  • cerebral cortex: 83 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.22
gnomAD pLI
0.99
gnomAD missense Z
1.98
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RBM4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBM4 as an antibody target. Whether an autoantibody or antibody against RBM4 could matter depends on whether native RBM4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBM4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBM4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RBM4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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