Seroatlas · Human Serome Atlas

SRSF10

Serine/arginine-rich splicing factor 10

Also known as: FUSIP1, FUSIP2, PPP1R149, SFRS13, SFRS13A, SRp38, SRrp40, SRS10_HUMAN, TASR1, TASR2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75494
Gene
SRSF10
Ensembl
ENSG00000188529
Chromosome
1
Canonical length
262 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein interacts with the oncoprotein TLS, and abrogates the influence of TLS on adenovirus E1A pre-mRNA splicing. This gene has pseudogenes on chromosomes 4, 9, 14, 18, and 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

262 residues, UniProt reviewed canonical sequence.

>O75494|SRSF10
     1  MSRYLRPPNT SLFVRNVADD TRSEDLRREF GRYGPIVDVY VPLDFYTRRP RGFAYVQFED
    61  VRDAEDALHN LDRKWICGRQ IEIQFAQGDR KTPNQMKAKE GRNVYSSSRY DDYDRYRRSR
   121  SRSYERRRSR SRSFDYNYRR SYSPRNSRPT GRPRRSRSHS DNDRFKHRNR SFSRSKSNSR
   181  SRSKSQPKKE MKAKSRSRSA SHTKTRGTSK TDSKTHYKSG SRYEKESRKK EPPRSKSQSR
   241  SQSRSRSKSR SRSWTSPKSS GH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRSF10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
113 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 113 nTPM
  • lymph node: 57 nTPM
  • tonsil: 54 nTPM
  • liver: 53 nTPM
  • thymus: 52 nTPM
  • adrenal gland: 49 nTPM

Single-cell type

  • erythrocyte progenitors: 294 nCPM
  • rod photoreceptor cells: 264 nCPM
  • extravillous trophoblasts: 261 nCPM
  • basal keratinocytes: 242 nCPM
  • early primary spermatocytes: 231 nCPM
  • tuft cells: 231 nCPM

Immune cell

  • basophil: 113 nTPM
  • intermediate monocyte: 84 nTPM
  • non-classical monocyte: 82 nTPM
  • memory B-cell: 81 nTPM
  • T-reg: 76 nTPM
  • NK-cell: 75 nTPM

Brain region

  • choroid plexus: 41 nTPM
  • white matter: 37 nTPM
  • cerebellum: 33 nTPM
  • spinal cord: 30 nTPM
  • hypothalamus: 30 nTPM
  • medulla oblongata: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.64
gnomAD pLI
0.42
gnomAD missense Z
0.59
DepMap mean gene effect
-0.7
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SRSF10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRSF10 as an antibody target. Whether an autoantibody or antibody against SRSF10 could matter depends on whether native SRSF10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRSF10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SRSF10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SRSF10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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