SF3B6
Splicing factor 3B subunit 6
Also known as: CGI-110, Ht006, P14, SAP14a, SF3B14a, SF3B6_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9Y3B4
- Gene
- SF3B6
- Ensembl
- ENSG00000115128
- Chromosome
- 2
- Canonical length
- 125 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
This gene encodes a 14 kDa protein subunit of the splicing factor 3b complex. Splicing factor 3b associates with both the U2 and U11/U12 small nuclear ribonucleoprotein complexes (U2 snRNP) of spliceosomes. This 14 kDa protein interacts directly with subunit 1 of the splicing factor 3b complex. This 14 kDa protein also interacts directly with the adenosine that carries out the first transesterification step of splicing at the pre-mRNA branch site. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
125 residues, UniProt reviewed canonical sequence.
>Q9Y3B4|SF3B6
1 MAMQAAKRAN IRLPPEVNRI LYIRNLPYKI TAEEMYDIFG KYGPIRQIRV GNTPETRGTA
61 YVVYEDIFDA KNACDHLSGF NVCNRYLVVL YYNANRAFQK MDTKKKEEQL KLLKEKYGIN
121 TDPPKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SF3B6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.36
- Highest tissue expression
- 199 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 199 nTPM
- epididymis: 134 nTPM
- esophagus: 131 nTPM
- breast: 129 nTPM
- thymus: 129 nTPM
- liver: 124 nTPM
Single-cell type
- esophageal apical cells: 1,245 nCPM
- esophageal suprabasal cells: 817 nCPM
- gastric progenitor cells: 651 nCPM
- esophageal basal cells: 564 nCPM
- extravillous trophoblasts: 531 nCPM
- suprabasal keratinocytes: 427 nCPM
Immune cell
- basophil: 225 nTPM
- eosinophil: 186 nTPM
- T-reg: 180 nTPM
- neutrophil: 175 nTPM
- memory B-cell: 155 nTPM
- total PBMC: 144 nTPM
Brain region
- white matter: 45 nTPM
- spinal cord: 38 nTPM
- medulla oblongata: 34 nTPM
- cerebellum: 34 nTPM
- hypothalamus: 33 nTPM
- pons: 30 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- DepMap mean gene effect
- -1.98
- DepMap dependency class
- pan
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of SF3B6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SF3B6 as an antibody target. Whether an autoantibody or antibody against SF3B6 could matter depends on whether native SF3B6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SF3B6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SF3B6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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