Seroatlas · Human Serome Atlas

RBM11

Splicing regulator RBM11

Also known as: RBM11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P57052
Gene
RBM11
Ensembl
ENSG00000185272
Chromosome
21
Canonical length
281 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables poly(U) RNA binding activity and protein homodimerization activity. Acts upstream of or within cellular response to oxidative stress and regulation of alternative mRNA splicing, via spliceosome. Located in nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

281 residues, UniProt reviewed canonical sequence.

>P57052|RBM11
     1  MFPAQEEADR TVFVGNLEAR VREEILYELF LQAGPLTKVT ICKDREGKPK SFGFVCFKHP
    61  ESVSYAIALL NGIRLYGRPI NVQYRFGSSR SSEPANQSFE SCVKINSHNY RNEEMLVGRS
   121  SFPMQYFPIN NTSLPQEYFL FQKMQWHVYN PVLQLPYYEM TAPLPNSASV SSSLNHVPDL
   181  EAGPSSYKWT HQQPSDSDLY QMTAPLPNSA SVSSSLNHVP DLEAGPSSYK WTHQQPSDSD
   241  LYQMNKRKRQ KQTSDSDSST DNNRGNECSQ KFRKSKKKKR Y

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBM11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
43 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 43 nTPM
  • spinal cord: 6.1 nTPM
  • hypothalamus: 2.9 nTPM
  • cerebral cortex: 2.7 nTPM
  • hippocampal formation: 2.7 nTPM
  • midbrain: 2.4 nTPM

Single-cell type

  • epididymal principal cells: 425 nCPM
  • oocytes: 74 nCPM
  • other brain neurons: 20 nCPM
  • epididymal basal cells: 20 nCPM
  • corticotrophs: 19 nCPM
  • retinal horizontal cells: 18 nCPM

Immune cell

  • naive CD4 T-cell: 1.2 nTPM
  • naive CD8 T-cell: 0.3 nTPM
  • memory CD4 T-cell: 0.2 nTPM
  • naive B-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • white matter: 2.5 nTPM
  • pons: 2.3 nTPM
  • midbrain: 2.2 nTPM
  • basal ganglia: 2 nTPM
  • hypothalamus: 1.8 nTPM
  • medulla oblongata: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.17
gnomAD pLI
0
gnomAD missense Z
0.38
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RBM11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBM11 as an antibody target. Whether an autoantibody or antibody against RBM11 could matter depends on whether native RBM11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBM11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBM11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RBM11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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