Seroatlas · Human Serome Atlas

HNRNPH1

Heterogeneous nuclear ribonucleoprotein H

Also known as: HNRH1_HUMAN, hnRNPH, HNRPH1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P31943
Gene
HNRNPH1
Ensembl
ENSG00000169045
Chromosome
5
Canonical length
449 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some may shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNA and is very similar to the family member HNRPF. This gene may be associated with hereditary lymphedema type I. Alternatively spliced transcript variants have been described [provided by RefSeq, Mar 2012]

Canonical amino-acid sequenceUniProt

449 residues, UniProt reviewed canonical sequence.

>P31943|HNRNPH1
     1  MMLGTEGGEG FVVKVRGLPW SCSADEVQRF FSDCKIQNGA QGIRFIYTRE GRPSGEAFVE
    61  LESEDEVKLA LKKDRETMGH RYVEVFKSNN VEMDWVLKHT GPNSPDTAND GFVRLRGLPF
   121  GCSKEEIVQF FSGLEIVPNG ITLPVDFQGR STGEAFVQFA SQEIAEKALK KHKERIGHRY
   181  IEIFKSSRAE VRTHYDPPRK LMAMQRPGPY DRPGAGRGYN SIGRGAGFER MRRGAYGGGY
   241  GGYDDYNGYN DGYGFGSDRF GRDLNYCFSG MSDHRYGDGG STFQSTTGHC VHMRGLPYRA
   301  TENDIYNFFS PLNPVRVHIE IGPDGRVTGE ADVEFATHED AVAAMSKDKA NMQHRYVELF
   361  LNSTAGASGG AYEHRYVELF LNSTAGASGG AYGSQMMGGM GLSNQSSYGG PASQQLSGGY
   421  GGGYGGQSSM SGYDQVLQEN SSDFQSNIA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HNRNPH1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
230 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 230 nTPM
  • spleen: 208 nTPM
  • thymus: 201 nTPM
  • choroid plexus: 192 nTPM
  • lymph node: 166 nTPM
  • cerebellum: 162 nTPM

Single-cell type

  • microglia: 366 nCPM
  • basal keratinocytes: 293 nCPM
  • gastric chief cells: 291 nCPM
  • mucous neck cells: 265 nCPM
  • choroid plexus epithelial cells: 245 nCPM
  • suprabasal keratinocytes: 233 nCPM

Immune cell

  • plasmacytoid DC: 91 nTPM
  • naive CD8 T-cell: 88 nTPM
  • MAIT T-cell: 83 nTPM
  • naive CD4 T-cell: 83 nTPM
  • T-reg: 83 nTPM
  • intermediate monocyte: 75 nTPM

Brain region

  • cerebellum: 89 nTPM
  • choroid plexus: 75 nTPM
  • cerebral cortex: 66 nTPM
  • basal ganglia: 63 nTPM
  • hypothalamus: 61 nTPM
  • thalamus: 60 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HNRNPH1.

Disease | AllUniProt

Conditions HNRNPH1 is implicated in, by any mechanism.

  • Neurodevelopmental disorder with craniofacial dysmorphism and skeletal defects (NEDCDS) MIM:620083

Disease | GeneticClinVar

9 pathogenic / likely-pathogenic of 116 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.11
gnomAD pLI
1
gnomAD missense Z
4.09
DepMap mean gene effect
-1.13
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HNRNPH1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HNRNPH1 as an antibody target. Whether an autoantibody or antibody against HNRNPH1 could matter depends on whether native HNRNPH1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HNRNPH1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HNRNPH1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HNRNPH1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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