Seroatlas · Human Serome Atlas

SREK1

Splicing regulatory glutamine/lysine-rich protein 1

Also known as: DKFZp564B176, SFRS12, SREK1_HUMAN, SRrp508, SRrp86

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WXA9
Gene: SREK1
Ensembl: ENSG00000153914
Chromosome: 5
Canonical length: 508 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear speckles
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a member of a family of serine/arginine-rich (SR) splicing proteins containing RNA recognition motif (RRM) domains. The encoded protein interacts with other SR proteins to modulate splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

508 residues, UniProt reviewed canonical sequence.

>Q8WXA9|SREK1
     1  MTSLMPGAGL LPIPTPNPLT TLGVSLSSLG AIPAAALDPN IATLGEIPQP PLMGNVDPSK
    61  IDEIRRTVYV GNLNSQTTTA DQLLEFFKQV GEVKFVRMAG DETQPTRFAF VEFADQNSVP
   121  RALAFNGVMF GDRPLKINHS NNAIVKPPEM TPQAAAKELE EVMKRVREAQ SFISAAIEPE
   181  SGKSNERKGG RSRSHTRSKS RSSSKSHSRR KRSQSKHRSR SHNRSRSRQK DRRRSKSPHK
   241  KRSKSRERRK SRSRSHSRDK RKDTREKIKE KERVKEKDRE KEREREKERE KEKERGKNKD
   301  RDKEREKDRE KDKEKDRERE REKEHEKDRD KEKEKEQDKE KEREKDRSKE IDEKRKKDKK
   361  SRTPPRSYNA SRRSRSSSRE RRRRRSRSSS RSPRTSKTIK RKSSRSPSPR SRNKKDKKRE
   421  KERDHISERR ERERSTSMRK SSNDRDGKEK LEKNSTSLKE KEHNKEPDSS VSKEVDDKDA
   481  PRTEENKIQH NGNCQLNEEN LSTKTEAV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SREK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 19 nTPM
cerebellum: 11 nTPM
retina: 8.8 nTPM
pancreas: 8.7 nTPM
endometrium: 8.5 nTPM
skin: 8.5 nTPM

Single-cell type

somatotrophs: 201 nCPM
thyrotrophs: 187 nCPM
neutrophil progenitors: 186 nCPM
lactotrophs: 175 nCPM
pituicytes/fscs: 171 nCPM
sertoli cells: 166 nCPM

Immune cell

basophil: 4.9 nTPM
naive B-cell: 3.8 nTPM
NK-cell: 3.8 nTPM
memory B-cell: 3.2 nTPM
plasmacytoid DC: 3.1 nTPM
eosinophil: 2.8 nTPM

Brain region

choroid plexus: 22 nTPM
cerebellum: 18 nTPM
cerebral cortex: 16 nTPM
white matter: 16 nTPM
hypothalamus: 16 nTPM
basal ganglia: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.35
gnomAD pLI: 0.91
gnomAD missense Z: 2.26
DepMap mean gene effect: -0.25
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

RNA recognition motif domain
Nucleotide-binding alpha-beta plait domain superfamily
RNA-binding domain superfamily
RNA recognition motif
SREK1, RNA recognition motif 2

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SREK1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SREK1 as an antibody target. Whether an autoantibody or antibody against SREK1 could matter depends on whether native SREK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SREK1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SREK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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