Seroatlas · Human Serome Atlas

PABPC1L2A

Polyadenylate-binding protein 1-like 2

Also known as: PABPC1L2B, PAP1M_HUMAN, RBM32A, RBM32B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5JQF8
Gene: PABPC1L2A
Ensembl: ENSG00000186288
Chromosome: X
Canonical length: 200 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable mRNA 3'-UTR binding activity; poly(A) binding activity; and poly(U) RNA binding activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

200 residues, UniProt reviewed canonical sequence.

>Q5JQF8|PABPC1L2A
     1  MASLYVGDLH PEVTEAMLYE KFSPAGPILS IRICRDKITR RSLGYAYVNY QQPVDAKRAL
    61  ETLNFDVIKG RPVRIMWSQR DPSLRKSGVG NVFIKNLGKT IDNKALYNIF SAFGNILSCK
   121  VACDEKGPKG YGFVHFQKQE SAERAIDVMN GMFLNYRKIF VGRFKSHKER EAERGAWARQ
   181  STSADVKDFE EDTDEEATLR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PABPC1L2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 7.9 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 7.9 nTPM
cerebral cortex: 6.5 nTPM
cerebellum: 5.8 nTPM
basal ganglia: 3.8 nTPM
hippocampal formation: 3 nTPM
amygdala: 2.8 nTPM

Single-cell type

other brain neurons: 8.4 nCPM
brain inhibitory neurons: 5.3 nCPM
prostatic glandular cells: 5.3 nCPM
brain excitatory neurons: 5.2 nCPM
oligodendrocyte progenitor cells: 3.6 nCPM
oligodendrocytes: 2.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 22 nTPM
hypothalamus: 18 nTPM
basal ganglia: 16 nTPM
white matter: 14 nTPM
midbrain: 13 nTPM
medulla oblongata: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.81
gnomAD pLI: 0.35
gnomAD missense Z: 1.03

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PABPC1L2A as an antibody target. Whether an autoantibody or antibody against PABPC1L2A could matter depends on whether native PABPC1L2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PABPC1L2A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PABPC1L2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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