Seroatlas · Human Serome Atlas

REXO5

RNA exonuclease 5

Also known as: NEF-sp, REXO5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96IC2
Gene: REXO5
Ensembl: ENSG00000005189
Chromosome: 16
Canonical length: 774 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear membrane,Nucleoli,Endoplasmic reticulum

OverviewNCBI Gene

Predicted to enable exonuclease activity. Predicted to be involved in rRNA 3'-end processing. Located in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

774 residues, UniProt reviewed canonical sequence.

>Q96IC2|REXO5
     1  MEPEREGTER HPRKVRESRQ APNKLVGAAE AMKAGWDLEE SQPEAKKARL STILFTDNCE
    61  VTHDQLCELL KYAVLGKSNV PKPSWCQLFH QNHLNNVVVF VLQGMSQLHF YRFYLEFGCL
   121  RKAFRHKFRL PPPSSDFLAD VVGLQTEQRA GDLPKTMEGP LPSNAKAAIN LQDDPIIQKY
   181  GSKKVGLTRC LLTKEEMRTF HFPLQGFPDC ENFLLTKCNG SIADNSPLFG LDCEMCLTSK
   241  GRELTRISLV AEGGCCVMDE LVKPENKILD YLTSFSGITK KILNPVTTKL KDVQRQLKAL
   301  LPPDAVLVGH SLDLDLRALK MIHPYVIDTS LLYVREQGRR FKLKFLAKVI LGKDIQCPDR
   361  LGHDATEDAR TILELARYFL KHGPKKIAEL NLEALANHQE IQAAGQEPKN TAEVLQHPNT
   421  SVLECLDSVG QKLLFLTRET DAGELPSSRN CQTIKCLSNK EVLEQARVEI PLFPFSIVQF
   481  SFKAFSPVLT EEMNKRMRIK WTEISTVYAG PFSKNCNLRA LKRLFKSFGP VQSMTFVLET
   541  RQPHLCIQYE VLEAAQLAIE SLDGILVDGI CIKVQRPVTE LTLDCDTLVN ELEGDSENQG
   601  SIYLSGVSET FKEQLLQEPR LFLGLEAVIL PKDLKSGKQK KYCFLKFKSF GSAQQALNIL
   661  TGKDWKLKGR HALTPRHLHA WLRGLPPEST RLPGLRVVPP PFEQEALQTL KLDHPKIAAW
   721  RWSRKIGKLY NSLCPGTLCL ILLPGTKSTH GSLSGLGLMG IKEEEESAGP GLCS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against REXO5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 322 nTPM

Expression across tissuesHPA

Tissue

testis: 322 nTPM
parathyroid gland: 38 nTPM
bone marrow: 11 nTPM
thymus: 6.9 nTPM
prostate: 5 nTPM
stomach: 4.8 nTPM

Single-cell type

late primary spermatocytes: 1,454 nCPM
epicardial cells: 450 nCPM
early primary spermatocytes: 332 nCPM
early spermatids: 327 nCPM
late spermatids: 51 nCPM
differentiating spermatogonia: 30 nCPM

Immune cell

basophil: 87 nTPM
eosinophil: 5.7 nTPM
NK-cell: 2.2 nTPM
T-reg: 1.7 nTPM
myeloid DC: 0.7 nTPM
classical monocyte: 0.4 nTPM

Brain region

hypothalamus: 7.4 nTPM
thalamus: 7.3 nTPM
cerebral cortex: 7.1 nTPM
white matter: 7.1 nTPM
medulla oblongata: 6.3 nTPM
pons: 6.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

DepMap mean gene effect: -0.03
DepMap dependency class: selective

OntologyGO

Biological processes

rRNA 3'-end processing

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads REXO5 as an antibody target. Whether an autoantibody or antibody against REXO5 could matter depends on whether native REXO5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

REXO5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label REXO5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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