RCAN1

Protein identityUniProt · HPA

UniProt accession

P53805

Gene

RCAN1

Ensembl

ENSG00000159200

Chromosome

21

Canonical length

252 aa

Protein class

Human disease related genes, Predicted intracellular proteins

Subcellular location

Cytosol

OverviewNCBI Gene

The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

Canonical amino-acid sequenceUniProt

252 residues, UniProt reviewed canonical sequence.

>P53805|RCAN1
     1  MEDGVAGPQL GAAAEAAEAA EARARPGVTL RPFAPLSGAA EADEGGGDWS FIDCEMEEVD
    61  LQDLPSATIA CHLDPRVFVD GLCRAKFESL FRTYDKDITF QYFKSFKRVR INFSNPFSAA
   121  DARLQLHKTE FLGKEMKLYF AQTLHIGSSH LAPPNPDKQF LISPPASPPV GWKQVEDATP
   181  VINYDLLYAI SKLGPGEKYE LHAATDTTPS VVVHVCESDQ EKEEEEEMER MRRPKPKIIQ
   241  TRRPEYTPIH LS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RCAN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.54

Highest tissue expression

426 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.07

gnomAD pLI

0.02

gnomAD missense Z

1.02

DepMap mean gene effect

0.08

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• calcineurin-NFAT signaling cascade
• calcium-mediated signaling
• locomotion involved in locomotory behavior
• negative regulation of calcineurin-NFAT signaling cascade
• negative regulation of smooth muscle cell differentiation
• response to estrogen
• response to ischemia
• response to mechanical stimulus
• response to oxidative stress
• short-term memory
• skeletal muscle fiber development

Molecular functions

• calcium-dependent protein serine/threonine phosphatase regulator activity
• identical protein binding
• nucleic acid binding
• protein phosphatase inhibitor activity

Cellular components

• cytoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Calcipressin
• Nucleotide-binding alpha-beta plait domain superfamily
• RNA-binding domain superfamily
• Calcipressin
• Calcipressin-1, RNA recognition motif

KeywordsUniProt

• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of RCAN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PPP3CA
• PPP3R1
• RAF1
• PPP3CB