Seroatlas · Human Serome Atlas

RAVER2

Ribonucleoprotein PTB-binding 2

Also known as: FLJ10770, KIAA1579, RAVR2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HCJ3
Gene: RAVER2
Ensembl: ENSG00000162437
Chromosome: 1
Canonical length: 691 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

691 residues, UniProt reviewed canonical sequence.

>Q9HCJ3|RAVER2
     1  MAAAAGDGGG EGGAGLGSAA GLGPGPGLRG QGPSAEAHEG APDPMPAALH PEEVAARLQR
    61  MQRELSNRRK ILVKNLPQDS NCQEVHDLLK DYDLKYCYVD RNKRTAFVTL LNGEQAQNAI
   121  QMFHQYSFRG KDLIVQLQPT DALLCITNVP ISFTSEEFEE LVRAYGNIER CFLVYSEVTG
   181  HSKGYGFVEY MKKDFAAKAR LELLGRQLGA SALFAQWMDV NLLASELIHS KCLCIDKLPS
   241  DYRDSEELLQ IFSSVHKPVF CQLAQDEGSY VGGFAVVEYS TAEQAEEVQQ AADGMTIKGS
   301  KVQVSFCAPG APGRSTLAAL IAAQRVMHSN QKGLLPEPNP VQIMKSLNNP AMLQVLLQPQ
   361  LCGRAVKPAV LGTPHSLPHL MNPSISPAFL HLNKAHQSSV MGNTSNLFLQ NLSHIPLAQQ
   421  QLMKFENIHT NNKPGLLGEP PAVVLQTALG IGSVLPLKKE LGHHHGEAHK TSSLIPTQTT
   481  ITAGMGMLPF FPNQHIAGQA GPGHSNTQEK QPATVGMAEG NFSGSQPYLQ SFPNLAAGSL
   541  LVGHHKQQQS QPKGTEISSG AASKNQTSLL GEPPKEIRLS KNPYLNLASV LPSVCLSSPA
   601  SKTTLHKTGI ASSILDAISQ GSESQHALEK CIAYSPPFGD YAQVSSLRNE KRGSSYLISA
   661  PEGGSVECVD QHSQGTGAYY METYLKKKRV Y

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAVER2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

rectum: 25 nTPM
small intestine: 25 nTPM
duodenum: 23 nTPM
colon: 22 nTPM
skeletal muscle: 21 nTPM
tongue: 17 nTPM

Single-cell type

choroid plexus epithelial cells: 179 nCPM
thyrotrophs: 162 nCPM
ependymal cells: 159 nCPM
astrocytes: 150 nCPM
bergmann glia: 141 nCPM
pituitary stem cells: 123 nCPM

Immune cell

basophil: 6.2 nTPM
myeloid DC: 0.5 nTPM
MAIT T-cell: 0.2 nTPM
plasmacytoid DC: 0.2 nTPM
gdT-cell: 0.1 nTPM
memory B-cell: 0.1 nTPM

Brain region

cerebellum: 24 nTPM
thalamus: 21 nTPM
hippocampal formation: 21 nTPM
amygdala: 20 nTPM
choroid plexus: 19 nTPM
midbrain: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.81
gnomAD pLI: 0
gnomAD missense Z: 0.72
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

RNA recognition motif domain
Nucleotide-binding alpha-beta plait domain superfamily
RNA-binding domain superfamily
Eukaryotic RNA-binding
RNA recognition motif
Ribonucleoprotein PTB-binding 2, RNA recognition motif 2
Ribonucleoprotein PTB-binding 2, RNA recognition motif 3
Ribonucleoprotein PTB-binding 2, RNA recognition motif 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAVER2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAVER2 as an antibody target. Whether an autoantibody or antibody against RAVER2 could matter depends on whether native RAVER2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAVER2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAVER2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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