Seroatlas · Human Serome Atlas

SRSF4

Serine/arginine-rich splicing factor 4

Also known as: SFRS4, SRP75, SRSF4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q08170
Gene: SRSF4
Ensembl: ENSG00000116350
Chromosome: 1
Canonical length: 494 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles

OverviewNCBI Gene

Enables RNA binding activity. Involved in negative regulation of mRNA splicing, via spliceosome. Located in nuclear speck. Biomarker of Down syndrome; acute myeloid leukemia; clear cell renal cell carcinoma; and colon adenocarcinoma. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

494 residues, UniProt reviewed canonical sequence.

>Q08170|SRSF4
     1  MPRVYIGRLS YQARERDVER FFKGYGKILE VDLKNGYGFV EFDDLRDADD AVYELNGKDL
    61  CGERVIVEHA RGPRRDGSYG SGRSGYGYRR SGRDKYGPPT RTEYRLIVEN LSSRCSWQDL
   121  KDYMRQAGEV TYADAHKGRK NEGVIEFVSY SDMKRALEKL DGTEVNGRKI RLVEDKPGSR
   181  RRRSYSRSRS HSRSRSRSRH SRKSRSRSGS SKSSHSKSRS RSRSGSRSRS KSRSRSQSRS
   241  RSKKEKSRSP SKEKSRSRSH SAGKSRSKSK DQAEEKIQNN DNVGKPKSRS PSRHKSKSKS
   301  RSRSQERRVE EEKRGSVSRG RSQEKSLRQS RSRSRSKGGS RSRSRSRSKS KDKRKGRKRS
   361  REESRSRSRS RSKSERSRKR GSKRDSKAGS SKKKKKEDTD RSQSRSPSRS VSKEREHAKS
   421  ESSQREGRGE SENAGTNQET RSRSRSNSKS KPNLPSESRS RSKSASKTRS RSKSRSRSAS
   481  RSPSRSRSRS HSRS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRSF4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 86 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 86 nTPM
liver: 84 nTPM
ovary: 82 nTPM
colon: 79 nTPM
lung: 78 nTPM
adipose tissue: 78 nTPM

Single-cell type

neutrophils: 336 nCPM
myonuclei: 326 nCPM
neutrophil progenitors: 314 nCPM
erythrocyte progenitors: 310 nCPM
syncytiotrophoblasts: 303 nCPM
esophageal apical cells: 302 nCPM

Immune cell

eosinophil: 102 nTPM
neutrophil: 90 nTPM
T-reg: 79 nTPM
basophil: 73 nTPM
memory CD8 T-cell: 70 nTPM
gdT-cell: 65 nTPM

Brain region

cerebral cortex: 39 nTPM
cerebellum: 36 nTPM
hypothalamus: 36 nTPM
thalamus: 35 nTPM
white matter: 35 nTPM
medulla oblongata: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.38
gnomAD pLI: 0.87
gnomAD missense Z: 2.4
DepMap mean gene effect: -0.2
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SRSF4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRSF4 as an antibody target. Whether an autoantibody or antibody against SRSF4 could matter depends on whether native SRSF4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRSF4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SRSF4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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