Seroatlas · Human Serome Atlas

RALY

RNA-binding protein Raly

Also known as: HNRPCL2, P542, RALY_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UKM9
Gene: RALY
Ensembl: ENSG00000125970
Chromosome: 20
Canonical length: 306 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

This gene encodes a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) gene family. This protein may play a role in pre-mRNA splicing and in embryonic development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

306 residues, UniProt reviewed canonical sequence.

>Q9UKM9|RALY
     1  MSLKLQASNV TNKNDPKSIN SRVFIGNLNT ALVKKSDVET IFSKYGRVAG CSVHKGYAFV
    61  QYSNERHARA AVLGENGRVL AGQTLDINMA GEPKPDRPKG LKRAASAIYS GYIFDYDYYR
   121  DDFYDRLFDY RGRLSPVPVP RAVPVKRPRV TVPLVRRVKT NVPVKLFARS TAVTTSSAKI
   181  KLKSSELQAI KTELTQIKSN IDALLSRLEQ IAAEQKANPD GKKKGDGGGA GGGGGGGGSG
   241  GGGSGGGGGG GSSRPPAPQE NTTSEAGLPQ GEARTRDDGD EEGLLTHSEE ELEHSQDTDA
   301  DDGALQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RALY can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 179 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 179 nTPM
skeletal muscle: 168 nTPM
blood vessel: 151 nTPM
thymus: 151 nTPM
heart muscle: 133 nTPM
colon: 128 nTPM

Single-cell type

neutrophils: 467 nCPM
esophageal apical cells: 381 nCPM
colonocytes: 378 nCPM
enterocytes: 370 nCPM
endometrial glandular cells: 357 nCPM
extravillous trophoblasts: 339 nCPM

Immune cell

eosinophil: 222 nTPM
non-classical monocyte: 197 nTPM
NK-cell: 187 nTPM
neutrophil: 174 nTPM
total PBMC: 165 nTPM
memory CD8 T-cell: 150 nTPM

Brain region

white matter: 133 nTPM
medulla oblongata: 113 nTPM
spinal cord: 105 nTPM
pons: 101 nTPM
basal ganglia: 101 nTPM
cerebellum: 101 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.64
gnomAD pLI: 0.14
gnomAD missense Z: 1.36
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RALY in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RALY as an antibody target. Whether an autoantibody or antibody against RALY could matter depends on whether native RALY is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RALY is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RALY as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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