Seroatlas · Human Serome Atlas

HTATSF1

17S U2 SnRNP complex component HTATSF1

Also known as: HTSF1_HUMAN, TAT-SF1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43719
Gene: HTATSF1
Ensembl: ENSG00000102241
Chromosome: X
Canonical length: 755 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene functions as a cofactor for the stimulation of transcriptional elongation by HIV-1 Tat, which binds to the HIV-1 promoter through Tat-TAR interaction. This protein may also serve as a dual-function factor to couple transcription and splicing and to facilitate their reciprocal activation. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Sep 2009]

Canonical amino-acid sequenceUniProt

755 residues, UniProt reviewed canonical sequence.

>O43719|HTATSF1
     1  MSGTNLDGND EFDEQLRMQE LYGDGKDGDT QTDAGGEPDS LGQQPTDTPY EWDLDKKAWF
    61  PKITEDFIAT YQANYGFSND GASSSTANVE DVHARTAEEP PQEKAPEPTD ARKKGEKRKA
   121  ESGWFHVEED RNTNVYVSGL PPDITVDEFI QLMSKFGIIM RDPQTEEFKV KLYKDNQGNL
   181  KGDGLCCYLK RESVELALKL LDEDEIRGYK LHVEVAKFQL KGEYDASKKK KKCKDYKKKL
   241  SMQQKQLDWR PERRAGPSRM RHERVVIIKN MFHPMDFEDD PLVLNEIRED LRVECSKFGQ
   301  IRKLLLFDRH PDGVASVSFR DPEEADYCIQ TLDGRWFGGR QITAQAWDGT TDYQVEETSR
   361  EREERLRGWE AFLNAPEANR GLRRSDSVSA SERAGPSRAR HFSEHPSTSK MNAQETATGM
   421  AFEEPIDEKK FEKTEDGGEF EEGASENNAK ESSPEKEAEE GCPEKESEEG CPKRGFEGSC
   481  SQKESEEGNP VRGSEEDSPK KESKKKTLKN DCEENGLAKE SEDDLNKESE EEVGPTKESE
   541  EDDSEKESDE DCSEKQSEDG SEREFEENGL EKDLDEEGSE KELHENVLDK ELEENDSENS
   601  EFEDDGSEKV LDEEGSEREF DEDSDEKEEE EDTYEKVFDD ESDEKEDEEY ADEKGLEAAD
   661  KKAEEGDADE KLFEESDDKE DEDADGKEVE DADEKLFEDD DSNEKLFDEE EDSSEKLFDD
   721  SDERGTLGGF GSVEEGPLST GSSFILSSDD DDDDI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HTATSF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 170 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 170 nTPM
pituitary gland: 141 nTPM
tongue: 102 nTPM
adrenal gland: 94 nTPM
spinal cord: 75 nTPM
hypothalamus: 71 nTPM

Single-cell type

lactotrophs: 325 nCPM
somatotrophs: 285 nCPM
thyrotrophs: 284 nCPM
adrenal medulla cells: 170 nCPM
syncytiotrophoblasts: 141 nCPM
differentiating spermatogonia: 130 nCPM

Immune cell

NK-cell: 50 nTPM
basophil: 48 nTPM
T-reg: 48 nTPM
naive CD4 T-cell: 45 nTPM
MAIT T-cell: 45 nTPM
memory CD4 T-cell: 45 nTPM

Brain region

hypothalamus: 104 nTPM
medulla oblongata: 65 nTPM
thalamus: 58 nTPM
spinal cord: 56 nTPM
midbrain: 56 nTPM
cerebellum: 55 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HTATSF1.

Disease | ImmuneIEDB

Conditions an epitope on HTATSF1 was assayed in.

melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.22
gnomAD pLI: 1
gnomAD missense Z: 1.98
DepMap mean gene effect: -0.65
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

RNA recognition motif domain
Nucleotide-binding alpha-beta plait domain superfamily
RNA-binding domain superfamily
RNA recognition motif
TatSF1-like, RNA recognition motif 1
TatSF1-like

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HTATSF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HTATSF1 as an antibody target. Whether an autoantibody or antibody against HTATSF1 could matter depends on whether native HTATSF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HTATSF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HTATSF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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