RBM46

Protein identityUniProt · HPA

UniProt accession

Q8TBY0

Gene

RBM46

Ensembl

ENSG00000151962

Chromosome

4

Canonical length

533 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoli fibrillar center,Cytosol

OverviewNCBI Gene

Predicted to enable mRNA binding activity. Predicted to be involved in several processes, including cell cycle switching, mitotic to meiotic cell cycle; meiotic nuclear division; and spermatid differentiation. Predicted to act upstream of or within mRNA stabilization and trophectodermal cell differentiation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

533 residues, UniProt reviewed canonical sequence.

>Q8TBY0|RBM46
     1  MNEENIDGTN GCSKVRTGIQ NEAALLALME KTGYNMVQEN GQRKFGGPPP GWEGPPPPRG
    61  CEVFVGKIPR DMYEDELVPV FERAGKIYEF RLMMEFSGEN RGYAFVMYTT KEEAQLAIRI
   121  LNNYEIRPGK FIGVCVSLDN CRLFIGAIPK EKKKEEILDE MKKVTEGVVD VIVYPSATDK
   181  TKNRGFAFVE YESHRAAAMA RRKLIPGTFQ LWGHTIQVDW ADPEKEVDEE TMQRVKVLYV
   241  RNLMISTTEE TIKAEFNKFK PGAVERVKKL RDYAFVHFFN REDAVAAMSV MNGKCIDGAS
   301  IEVTLAKPVN KENTWRQHLN GQISPNSENL IVFANKEESH PKTLGKLPTL PARLNGQHSP
   361  SPPEVERCTY PFYPGTKLTP ISMYSLKSNH FNSAVMHLDY YCNKNNWAPP EYYLYSTTSQ
   421  DGKVLLVYKI VIPAIANGSQ SYFMPDKLCT TLEDAKELAA QFTLLHLDYN FHRSSINSLS
   481  PVSATLSSGT PSVLPYTSRP YSYPGYPLSP TISLANGSHV GQRLCISNQA SFF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBM46 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.41

Highest tissue expression

26 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.48

gnomAD pLI

0.47

gnomAD missense Z

2.1

DepMap mean gene effect

0.02

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• female meiotic nuclear division
• male meiotic nuclear division
• mRNA stabilization
• oogenesis
• spermatid differentiation
• spermatogenesis
• trophectodermal cell differentiation
• cell cycle switching, mitotic to meiotic cell cycle

Molecular functions

• enzyme-substrate adaptor activity
• mRNA binding

Cellular components

• apolipoprotein B mRNA editing enzyme complex
• cytoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• RNA recognition motif domain
• HnRNP R/Q splicing factor
• Nucleotide-binding alpha-beta plait domain superfamily
• RNA-binding domain superfamily
• RNA recognition motif
• double strand RNA binding domain from DEAD END PROTEIN 1
• Probable RNA-binding protein 46, RNA recognition motif 1
• Probable RNA-binding protein 46, RNA recognition motif 2
• RBM46, double-stranded RNA binding domain
• Probable RNA-binding protein 46, RNA recognition motif 3

KeywordsUniProt

• Cytoplasm
• Differentiation
• Meiosis
• Oogenesis
• Repeat
• RNA-binding
• Spermatogenesis

InteractionsUniProt · HPA

Protein binding partners of RBM46 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CNOT6L
• DDX4
• MEIOC
• MOV10
• PABPC1
• UPF1
• YTHDC2