Seroatlas · Human Serome Atlas

PABPC3

Polyadenylate-binding protein 3

Also known as: PABP3, PABP3_HUMAN, PABPL3, tPABP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H361
Gene: PABPC3
Ensembl: ENSG00000151846
Chromosome: 13
Canonical length: 631 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Messenger RNA stability and translation initiation are extensively under the control of poly(A)-binding proteins (PABP). See PABPC1 (MIM 604679) for background information.[supplied by OMIM, Jul 2002]

Canonical amino-acid sequenceUniProt

631 residues, UniProt reviewed canonical sequence.

>Q9H361|PABPC3
     1  MNPSTPSYPT ASLYVGDLHP DVTEAMLYEK FSPAGPILSI RICRDLITSG SSNYAYVNFQ
    61  HTKDAEHALD TMNFDVIKGK PVRIMWSQRD PSLRKSGVGN IFVKNLDKSI NNKALYDTVS
   121  AFGNILSCNV VCDENGSKGY GFVHFETHEA AERAIKKMNG MLLNGRKVFV GQFKSRKERE
   181  AELGARAKEF PNVYIKNFGE DMDDERLKDL FGKFGPALSV KVMTDESGKS KGFGFVSFER
   241  HEDAQKAVDE MNGKELNGKQ IYVGRAQKKV ERQTELKRTF EQMKQDRITR YQVVNLYVKN
   301  LDDGIDDERL RKAFSPFGTI TSAKVMMEGG RSKGFGFVCF SSPEEATKAV TEMNGRIVAT
   361  KPLYVALAQR KEERQAYLTN EYMQRMASVR AVPNQRAPPS GYFMTAVPQT QNHAAYYPPS
   421  QIARLRPSPR WTAQGARPHP FQNKPSAIRP GAPRVPFSTM RPASSQVPRV MSTQRVANTS
   481  TQTVGPRPAA AAAAAATPAV RTVPRYKYAA GVRNPQQHRN AQPQVTMQQL AVHVQGQETL
   541  TASRLASAPP QKQKQMLGER LFPLIQAMHP TLAGKITGML LEIDNSELLY MLESPESLRS
   601  KVDEAVAVLQ AHQAKEATQK AVNSATGVPT V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PABPC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

testis: 34 nTPM
cerebral cortex: 0.2 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM
midbrain: 0.1 nTPM
retina: 0.1 nTPM

Single-cell type

late primary spermatocytes: 132 nCPM
early spermatids: 20 nCPM
early primary spermatocytes: 14 nCPM
papillary tip epithelial cells: 5.7 nCPM
late spermatids: 3.1 nCPM
renal connecting tubule cells: 3 nCPM

Immune cell

total PBMC: 0.5 nTPM
intermediate monocyte: 0.4 nTPM
myeloid DC: 0.4 nTPM
naive CD4 T-cell: 0.4 nTPM
naive CD8 T-cell: 0.4 nTPM
non-classical monocyte: 0.4 nTPM

Brain region

thalamus: 0.6 nTPM
basal ganglia: 0.5 nTPM
cerebellum: 0.5 nTPM
medulla oblongata: 0.5 nTPM
pons: 0.5 nTPM
spinal cord: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.67
gnomAD pLI: 0
gnomAD missense Z: -0.78
DepMap mean gene effect: 0.16
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

mRNA metabolic process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PABPC3 as an antibody target. Whether an autoantibody or antibody against PABPC3 could matter depends on whether native PABPC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PABPC3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PABPC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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