TIAL1

Protein identityUniProt · HPA

UniProt accession

Q01085

Gene

TIAL1

Ensembl

ENSG00000151923

Chromosome

10

Canonical length

375 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

375 residues, UniProt reviewed canonical sequence.

>Q01085|TIAL1
     1  MMEDDGQPRT LYVGNLSRDV TEVLILQLFS QIGPCKSCKM ITEHTSNDPY CFVEFYEHRD
    61  AAAALAAMNG RKILGKEVKV NWATTPSSQK KDTSNHFHVF VGDLSPEITT EDIKSAFAPF
   121  GKISDARVVK DMATGKSKGY GFVSFYNKLD AENAIVHMGG QWLGGRQIRT NWATRKPPAP
   181  KSTQENNTKQ LRFEDVVNQS SPKNCTVYCG GIASGLTDQL MRQTFSPFGQ IMEIRVFPEK
   241  GYSFVRFSTH ESAAHAIVSV NGTTIEGHVV KCYWGKESPD MTKNFQQVDY SQWGQWSQVY
   301  GNPQQYGQYM ANGWQVPPYG VYGQPWNQQG FGVDQSPSAA WMGGFGAQPP QGQAPPPVIP
   361  PPNQAGYGMA SYQTQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TIAL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.43

Highest tissue expression

46 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.11

gnomAD pLI

1

gnomAD missense Z

3.58

DepMap mean gene effect

-0.1

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic process
• defense response
• negative regulation of cell population proliferation
• positive regulation of hippo signaling
• positive regulation of miRNA-mediated gene silencing
• regulation of transcription by RNA polymerase II

Molecular functions

• DNA binding
• mRNA 3'-UTR binding
• protein-RNA adaptor activity
• RNA binding

Cellular components

• cytolytic granule
• cytoplasm
• cytoplasmic stress granule
• cytosol
• lysosome
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• RNA recognition motif domain
• RNA recognition motif domain, eukaryotic-type
• Nucleotide-binding alpha-beta plait domain superfamily
• TIAR, RNA recognition motif 3
• RNA-binding domain superfamily
• RNA recognition motif
• TIAR, RNA recognition motif 1
• TIAR, RNA recognition motif 2

KeywordsUniProt

• Acetylation
• Apoptosis
• Cytoplasm
• Lysosome
• Nucleus
• Phosphoprotein
• Repeat
• RNA-binding

InteractionsUniProt · HPA

Protein binding partners of TIAL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• FASTK
• DZIP3