EIF4H

Protein identityUniProt · HPA

UniProt accession

Q15056

Gene

EIF4H

Ensembl

ENSG00000106682

Chromosome

7

Canonical length

248 aa

Protein class

Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

This gene encodes one of the translation initiation factors, which functions to stimulate the initiation of protein synthesis at the level of mRNA utilization. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

248 residues, UniProt reviewed canonical sequence.

>Q15056|EIF4H
     1  MADFDTYDDR AYSSFGGGRG SRGSAGGHGS RSQKELPTEP PYTAYVGNLP FNTVQGDIDA
    61  IFKDLSIRSV RLVRDKDTDK FKGFCYVEFD EVDSLKEALT YDGALLGDRS LRVDIAEGRK
   121  QDKGGFGFRK GGPDDRGMGS SRESRGGWDS RDDFNSGFRD DFLGGRGGSR PGDRRTGPPM
   181  GSRFRDGPPL RGSNMDFREP TEEERAQRPR LQLKPRTVAT PLNQVANPNS AIFGGARPRE
   241  EVVQKEQE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EIF4H can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.58

Highest tissue expression

375 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.55

gnomAD pLI

0.44

gnomAD missense Z

2.51

DepMap mean gene effect

-0.29

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• developmental growth
• eukaryotic translation initiation factor 4F complex assembly
• formation of translation preinitiation complex
• regulation of translational initiation

Molecular functions

• cadherin binding
• ribosomal small subunit binding
• RNA binding
• RNA strand annealing activity
• RNA strand-exchange activity
• translation factor activity, RNA binding
• translation initiation factor activity

Cellular components

• cytosol
• eukaryotic translation initiation factor 4F complex
• membrane
• perinuclear region of cytoplasm

Protein domainsUniProt · Pfam · InterPro

• RNA recognition motif domain
• Nucleotide-binding alpha-beta plait domain superfamily
• RNA-binding domain superfamily
• RNA recognition motif
• eIF4H, RNA recognition motif

KeywordsUniProt

• Acetylation
• Cytoplasm
• Host-virus interaction
• Initiation factor
• Methylation
• Phosphoprotein
• Protein biosynthesis
• RNA-binding
• Williams-Beuren syndrome

InteractionsUniProt · HPA

Protein binding partners of EIF4H in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• BTF3
• EIF4A1