Seroatlas · Human Serome Atlas

HNRNPR

Heterogeneous nuclear ribonucleoprotein R

Also known as: hnRNP-R, HNRPR, HNRPR_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43390
Gene
HNRNPR
Ensembl
ENSG00000125944
Chromosome
1
Canonical length
633 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes an RNA-binding protein that is a member of the spliceosome C complex, which functions in pre-mRNA processing and transport. The encoded protein also promotes transcription at the c-fos gene. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes 4, 11, and 10. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

633 residues, UniProt reviewed canonical sequence.

>O43390|HNRNPR
     1  MANQVNGNAV QLKEEEEPMD TSSVTHTEHY KTLIEAGLPQ KVAERLDEIF QTGLVAYVDL
    61  DERAIDALRE FNEEGALSVL QQFKESDLSH VQNKSAFLCG VMKTYRQREK QGSKVQESTK
   121  GPDEAKIKAL LERTGYTLDV TTGQRKYGGP PPDSVYSGVQ PGIGTEVFVG KIPRDLYEDE
   181  LVPLFEKAGP IWDLRLMMDP LSGQNRGYAF ITFCGKEAAQ EAVKLCDSYE IRPGKHLGVC
   241  ISVANNRLFV GSIPKNKTKE NILEEFSKVT EGLVDVILYH QPDDKKKNRG FCFLEYEDHK
   301  SAAQARRRLM SGKVKVWGNV VTVEWADPVE EPDPEVMAKV KVLFVRNLAT TVTEEILEKS
   361  FSEFGKLERV KKLKDYAFVH FEDRGAAVKA MDEMNGKEIE GEEIEIVLAK PPDKKRKERQ
   421  AARQASRSTA YEDYYYHPPP RMPPPIRGRG RGGGRGGYGY PPDYYGYEDY YDDYYGYDYH
   481  DYRGGYEDPY YGYDDGYAVR GRGGGRGGRG APPPPRGRGA PPPRGRAGYS QRGAPLGPPR
   541  GSRGGRGGPA QQQRGRGSRG SRGNRGGNVG GKRKADGYNQ PDSKRRQTNN QQNWGSQPIA
   601  QQPLQQGGDY SGNYGYNNDN QEFYQDTYGQ QWK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HNRNPR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
67 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 67 nTPM
  • endometrium: 61 nTPM
  • ovary: 57 nTPM
  • cerebellum: 57 nTPM
  • tonsil: 56 nTPM
  • lymph node: 54 nTPM

Single-cell type

  • erythrocyte progenitors: 109 nCPM
  • megakaryocyte progenitors: 106 nCPM
  • oligodendrocyte progenitor cells: 104 nCPM
  • choroid plexus epithelial cells: 91 nCPM
  • oligodendrocytes: 89 nCPM
  • podocytes: 88 nCPM

Immune cell

  • T-reg: 59 nTPM
  • NK-cell: 54 nTPM
  • MAIT T-cell: 52 nTPM
  • gdT-cell: 49 nTPM
  • non-classical monocyte: 48 nTPM
  • naive CD4 T-cell: 48 nTPM

Brain region

  • white matter: 48 nTPM
  • cerebellum: 48 nTPM
  • choroid plexus: 41 nTPM
  • hypothalamus: 40 nTPM
  • cerebral cortex: 39 nTPM
  • medulla oblongata: 39 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HNRNPR.

Disease | AllUniProt

Conditions HNRNPR is implicated in, by any mechanism.

  • Neurodevelopmental disorder with dysmorphic facies and skeletal and brain abnormalities (NEDDFSB) MIM:620073

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 106 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.21
gnomAD pLI
1
gnomAD missense Z
3.54
DepMap mean gene effect
-0.3
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HNRNPR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HNRNPR as an antibody target. Whether an autoantibody or antibody against HNRNPR could matter depends on whether native HNRNPR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HNRNPR is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HNRNPR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HNRNPR. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...