Seroatlas · Human Serome Atlas

RNPS1

RNA-binding protein with serine-rich domain 1

Also known as: RNPS1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15287
Gene
RNPS1
Ensembl
ENSG00000205937
Chromosome
16
Canonical length
305 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. This protein contains many serine residues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Canonical amino-acid sequenceUniProt

305 residues, UniProt reviewed canonical sequence.

>Q15287|RNPS1
     1  MDLSGVKKKS LLGVKENNKK SSTRAPSPTK RKDRSDEKSK DRSKDKGATK ESSEKDRGRD
    61  KTRKRRSASS GSSSTRSRSS STSSSGSSTS TGSSSGSSSS SASSRSGSSS TSRSSSSSSS
   121  SGSPSPSRRR HDNRRRSRSK SKPPKRDEKE RKRRSPSPKP TKVHIGRLTR NVTKDHIMEI
   181  FSTYGKIKMI DMPVERMHPH LSKGYAYVEF ENPDEAEKAL KHMDGGQIDG QEITATAVLA
   241  PWPRPPPRRF SPPRRMLPPP PMWRRSPPRM RRRSRSPRRR SPVRRRSRSP GRRRHRSRSS
   301  SNSSR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNPS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
202 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 202 nTPM
  • cerebellum: 153 nTPM
  • bone marrow: 137 nTPM
  • cerebral cortex: 135 nTPM
  • hypothalamus: 112 nTPM
  • amygdala: 107 nTPM

Single-cell type

  • differentiating spermatogonia: 298 nCPM
  • extravillous trophoblasts: 276 nCPM
  • migrating cytotrophoblasts: 258 nCPM
  • oocytes: 230 nCPM
  • cytotrophoblasts: 207 nCPM
  • esophageal basal cells: 196 nCPM

Immune cell

  • total PBMC: 290 nTPM
  • naive B-cell: 206 nTPM
  • T-reg: 197 nTPM
  • non-classical monocyte: 189 nTPM
  • NK-cell: 183 nTPM
  • memory B-cell: 178 nTPM

Brain region

  • cerebral cortex: 191 nTPM
  • pons: 159 nTPM
  • hypothalamus: 155 nTPM
  • basal ganglia: 153 nTPM
  • white matter: 145 nTPM
  • hippocampal formation: 144 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.25
gnomAD pLI
0.98
gnomAD missense Z
1.19
DepMap mean gene effect
-0.9
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RNPS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNPS1 as an antibody target. Whether an autoantibody or antibody against RNPS1 could matter depends on whether native RNPS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNPS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNPS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RNPS1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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