Seroatlas · Human Serome Atlas

RBM15B

Putative RNA-binding protein 15B

Also known as: HUMAGCGB, OTT3, RB15B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NDT2
Gene: RBM15B
Ensembl: ENSG00000259956
Chromosome: 3
Canonical length: 890 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Members of the SPEN (Split-end) family of proteins, including RBM15B, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb 2009]

Canonical amino-acid sequenceUniProt

890 residues, UniProt reviewed canonical sequence.

>Q8NDT2|RBM15B
     1  MKRQSERDSS PSGRGSSSSA KRPREREREA EAGGRRAAHK ASGGAKHPVP ARARDKPRGS
    61  GSGGGGHRDG RGTGDANHRA SSGRSSGSGA GGGGRGGKAS GDPGASGMSP RASPLPPPPP
   121  PPGAEPACPG SSAAAPEYKT LLISSLSPAL PAEHLEDRLF HQFKRFGEIS LRLSHTPELG
   181  RVAYVNFRHP QDAREARQHA LARQLLLYDR PLKVEPVYLR GGGGSSRRSS SSSAAASTPP
   241  PGPPAPADPL GYLPLHGGYQ YKQRSLSPVA APPLREPRAR HAAAAFALDA AAAAAVGLSR
   301  ERALDYYGLY DDRGRPYGYP AVCEEDLMPE DDQRATRNLF IGNLDHSVSE VELRRAFEKY
   361  GIIEEVVIKR PARGQGGAYA FLKFQNLDMA HRAKVAMSGR VIGRNPIKIG YGKANPTTRL
   421  WVGGLGPNTS LAALAREFDR FGSIRTIDHV KGDSFAYIQY ESLDAAQAAC AKMRGFPLGG
   481  PDRRLRVDFA KAEETRYPQQ YQPSPLPVHY ELLTDGYTRH RNLDADLVRD RTPPHLLYSD
   541  RDRTFLEGDW TSPSKSSDRR NSLEGYSRSV RSRSGERWGA DGDRGLPKPW EERRKRRSLS
   601  SDRGRTTHSP YEERSRTKGS GQQSERGSDR TPERSRKENH SSEGTKESSS NSLSNSRHGA
   661  EERGHHHHHH EAADSSHGKK ARDSERNHRT TEAEPKPLEE PKHETKKLKN LSEYAQTLQL
   721  GWNGLLVLKN SCFPTSMHIL EGDQGVISSL LKDHTSGSKL TQLKIAQRLR LDQPKLDEVT
   781  RRIKQGSPNG YAVLLATQAT PSGLGTEGMP TVEPGLQRRL LRNLVSYLKQ KQAAGVISLP
   841  VGGSKGRDGT GMLYAFPPCD FSQQYLQSAL RTLGKLEEEH MVIVIVRDTA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBM15B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

thymus: 18 nTPM
pancreas: 17 nTPM
esophagus: 17 nTPM
skin: 16 nTPM
endometrium: 16 nTPM
blood vessel: 14 nTPM

Single-cell type

esophageal apical cells: 42 nCPM
kupffer cells: 41 nCPM
esophageal suprabasal cells: 37 nCPM
esophageal basal cells: 32 nCPM
suprabasal keratinocytes: 31 nCPM
epididymal clear cells: 31 nCPM

Immune cell

intermediate monocyte: 2.8 nTPM
non-classical monocyte: 2.8 nTPM
naive B-cell: 2.5 nTPM
memory CD4 T-cell: 2.3 nTPM
naive CD4 T-cell: 2.3 nTPM
plasmacytoid DC: 2.3 nTPM

Brain region

cerebral cortex: 20 nTPM
midbrain: 20 nTPM
amygdala: 19 nTPM
hippocampal formation: 19 nTPM
medulla oblongata: 19 nTPM
thalamus: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.25
gnomAD pLI: 1
gnomAD missense Z: 2.32
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

RNA recognition motif domain
Spen paralogue/orthologue C-terminal, metazoa
Nucleotide-binding alpha-beta plait domain superfamily
Spen paralogue and orthologue SPOC, C-terminal
SPOC-like, C-terminal domain superfamily
RNA-binding domain superfamily
RNA recognition motif
SPOC domain
RBM15B, RNA recognition motif 1
RBM15B, RNA recognition motif 2
RBM15B, RNA recognition motif 3

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RBM15B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBM15B as an antibody target. Whether an autoantibody or antibody against RBM15B could matter depends on whether native RBM15B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBM15B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBM15B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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