SNRNP70

Protein identityUniProt · HPA

UniProt accession

P08621

Gene

SNRNP70

Ensembl

ENSG00000104852

Chromosome

19

Canonical length

437 aa

Protein class

Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm

OverviewNCBI Gene

Enables U1 snRNA binding activity. Involved in mRNA splicing, via spliceosome and regulation of RNA splicing. Located in nucleoplasm. Part of U1 snRNP and spliceosomal complex. Implicated in disease of mental health and systemic lupus erythematosus. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

437 residues, UniProt reviewed canonical sequence.

>P08621|SNRNP70
     1  MTQFLPPNLL ALFAPRDPIP YLPPLEKLPH EKHHNQPYCG IAPYIREFED PRDAPPPTRA
    61  ETREERMERK RREKIERRQQ EVETELKMWD PHNDPNAQGD AFKTLFVARV NYDTTESKLR
   121  REFEVYGPIK RIHMVYSKRS GKPRGYAFIE YEHERDMHSA YKHADGKKID GRRVLVDVER
   181  GRTVKGWRPR RLGGGLGGTR RGGADVNIRH SGRDDTSRYD ERPGPSPLPH RDRDRDRERE
   241  RRERSRERDK ERERRRSRSR DRRRRSRSRD KEERRRSRER SKDKDRDRKR RSSRSRERAR
   301  RERERKEELR GGGGDMAEPS EAGDAPPDDG PPGELGPDGP DGPEEKGRDR DRERRRSHRS
   361  ERERRRDRDR DRDRDREHKR GERGSERGRD EARGGGGGQD NGLEGLGNDS RDMYMESEGG
   421  DGYLAPENGY LMEAAPE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNRNP70 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.54

Highest tissue expression

136 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SNRNP70.

Disease | ImmuneIEDB

Conditions an epitope on SNRNP70 was assayed in.

• systemic lupus erythematosus B and T cell
• mixed connective tissue disease B and T cell
• rheumatoid arthritis T cell
• viral infectious disease T cell

Disease | AutoantibodyPubMed

Conditions in which antibodies against SNRNP70 are reported. Each links to that disease's full target list.

• Lupus Erythematosus, Systemic 81
• Scleroderma, Systemic 51
• Mixed Connective Tissue Disease 47
• Lupus Erythematosus, Cutaneous 12
• Hypertension, Pulmonary 11
• Sjogren's Syndrome 11
• Raynaud Disease 9
• Heart Block 8
• Myositis 8
• Dermatomyositis 7
• Collagen Diseases 5
• Lung Diseases, Interstitial 5
• Lupus Nephritis 5
• Lupus Vasculitis, Central Nervous System 5
• Arthritis, Rheumatoid 4
• Polymyositis 4
• Arthritis 3
• Pulmonary Fibrosis 3
• Scleroderma, Localized 3

Showing 19 of 21 — disease pages carrying at least 10 antigens.

ReferencesPubMed · IEDB

Publications for SNRNP70 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.19

gnomAD pLI

1

gnomAD missense Z

3.45

DepMap mean gene effect

-1.1

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular response to retinoic acid
• cellular response to transforming growth factor beta stimulus
• cellular response to tumor necrosis factor
• mRNA splicing, via spliceosome
• negative regulation of chaperone-mediated autophagy
• negative regulation of protein refolding
• positive regulation of mRNA splicing, via spliceosome
• regulation of RNA splicing

Molecular functions

• mRNA binding
• RNA binding
• U1 snRNA binding
• U1 snRNP binding

Cellular components

• lysosomal lumen
• nuclear speck
• nucleoplasm
• nucleus
• spliceosomal complex
• U1 snRNP
• U2-type prespliceosome

Protein domainsUniProt · Pfam · InterPro

• RNA recognition motif domain
• Nucleotide-binding alpha-beta plait domain superfamily
• RNA-binding domain superfamily
• U1 snRNP 70 kDa and U11/U12 snRNP 35 kDa
• RNA recognition motif
• U1 small nuclear ribonucleoprotein of 70kDa N-terminal
• snRNP70, RNA recognition motif
• U1 small nuclear ribonucleoprotein of 70kDa MW N terminal

KeywordsUniProt

• Acetylation
• Isopeptide bond
• mRNA processing
• Nucleus
• Phosphoprotein
• Ribonucleoprotein
• RNA-binding
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of SNRNP70 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CPSF6
• FUS
• GEMIN5
• SCAF11
• SCNM1
• SFPQ
• NUDT21
• SRSF10
• RBM5
• CTDP1
• CLK2
• DDX21
• RNPS1
• SMN1
• SNRPA
• SNRPB
• SNRPB2
• SNRPC
• SNRPD2
• SNRPF
• SRPK1
• SRPK2
• SRSF1
• TOP1