NXF2

Protein identityUniProt · HPA

UniProt accession

Q9GZY0

Gene

NXF2

Ensembl

ENSG00000269405

Chromosome

X

Canonical length

626 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of a family of nuclear RNA export proteins. The encoded protein is associated with the nuclear envelope and aids in the export of mRNAs. There is a closely related paralog of this gene located adjacent on chromosome X and on the opposite strand. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

626 residues, UniProt reviewed canonical sequence.

>Q9GZY0|NXF2
     1  MCSTLKKCGT YRTEVAECHD HGSTFQGRKK GGSSFRDNFD KRSCHYEHGG YERPPSHCQE
    61  NDGSVEMRDV HKDQQLRHTP YSIRCERRMK WHSEDEIRIT TWRNRKPPER KMSQNTQDGY
   121  TRNWFKVTIP YGIKYDKAWL MNSIQSHCSD RFTPVDFHYV RNRACFFVQD ASAASALKDV
   181  SYKIYDDENQ KICIFVNHST APYSVKNKLK PGQMEMLKLT MNKRYNVSQQ ALDLQNLRFD
   241  PDLMGRDIDI ILNRRNCMAA TLKIIERNFP ELLSLNLCNN KLYQLDGLSD ITEKAPKVKT
   301  LNLSKNKLES AWELGKVKGL KLEELWLEGN PLCSTFSDQS AYVSAIRDCF PKLLRLDGRE
   361  LSAPVIVDID SSETMKPCKE NFTGSETLKH LVLQFLQQYY SIYDSGDRQG LLGAYHDEAC
   421  FSLAIPFDPK DSAPSSLCKY FEDSRNMKTL KDPYLKGELL RRTKRDIVDS LSALPKTQHD
   481  LSSILVDVWC QTERMLCFSV NGVFKEVEGQ SQGSVLAFTR TFIATPGSSS SLCIVNDELF
   541  VRDASPQETQ SAFSIPVSTL SSSSEPSLSQ EQQEMVQAFS AQSGMKLEWS QKCLQDNEWN
   601  YTRAGQAFTM LQTEGKIPAE AFKQIS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NXF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.4

Highest tissue expression

14 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.86

gnomAD pLI

0.45

gnomAD missense Z

1.48

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• mRNA export from nucleus
• poly(A)+ mRNA export from nucleus
• RNA transport

Molecular functions

• RNA binding

Cellular components

• cytoplasm
• cytosol
• nuclear RNA export factor complex
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Leucine-rich repeat
• Nuclear transport factor 2 domain
• TAP C-terminal (TAP-C) domain
• UBA-like superfamily
• Nucleotide-binding alpha-beta plait domain superfamily
• Nuclear RNA export factor Tap, RNA-binding domain
• Nuclear transport factor 2, eukaryote
• Nuclear RNA export factor
• Leucine-rich repeat domain superfamily
• NTF2-like domain superfamily
• RNA-binding domain superfamily
• NXF1/2/3/5-like, leucine-rich repeat domain
• TAP C-terminal domain
• Tap, RNA-binding
• Nuclear RNA export factor, NTF2 domain
• NXF1/2/3/5 leucine-rich repeat domain

KeywordsUniProt

• Cytoplasm
• Leucine-rich repeat
• mRNA transport
• Nucleus
• Phosphoprotein
• Repeat
• RNA-binding
• Transport

InteractionsUniProt · HPA

Protein binding partners of NXF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• E1B-AP5
• LUZP4
• NXT1
• NXT2
• FMR1